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Targeted Allele Detail
Symbol: Ptentm1Hwu
Name: phosphatase and tensin homolog; targeted mutation 1, Hong Wu
MGI ID: MGI:2156086
Synonyms: Ptenex5lox, PTENF, Ptenfl, Ptenflox, Ptenflx, Ptenfx, Ptenlox, Ptenloxp
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm1Hwu page
Ovary tumors in Pik3catm1.1Waph/Pik3catm1.1Waph Ptentm1Hwu/Ptentm1Hwu mice

Show the 16 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:75117
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP flanked hygromycin resistance cassette was inserted 5' to exon 5, and a single loxP site was inserted 3' to exon 5, which encodes the phosphatase domain. The hygromycin cassette was removed in ES cells by transient Cre recombinase expression prior to the production of chimeric mice, leaving a single loxP site in place of the cassette. These insertions do not appear to have any effect on the normal function of the gene. (J:75117)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 347 assay results
7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 91 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ptentm1Hwu
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 16 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  83 strains or lines available
Phenotypic Similarity to Human Syndrome: PTEN Hamartoma Tumor Syndrome (see OMIM:601728 Phosphatase And Tensin Homolog; PTEN) J:199362
Original:  J:75117 Lesche R, et al., Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis. 2002 Feb;32(2):148-9
All:  747 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
The Jackson Laboratory