Gata3^tm1Iho
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1Iho
• Name: GATA binding protein 3; targeted mutation 1, I-Cheng Ho
• MGI ID: MGI:2683927
• Synonyms: FF, Gata3^Ho
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1Iho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86996
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A genomic fragment containing the endogenous exons 4 and 5 was replaced with a loxP flanked cassette containing exons 4, 5, and 6 followed by neo. A PGK promoter and EGFP were included 5' and 3' of the floxed region, respectively, such that recombination of the loxP sites will place EGFP under control of the PGK promoter. (J:86996)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 31 strains or lines available

References

• Original: J:86996 Pai SY, et al., Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 2003 Dec;19(6):863-75
• All: 25 reference(s)