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Tg(DO11.10)10Dlo
Transgene Detail
Summary
Symbol: Tg(DO11.10)10Dlo
Name: transgene insertion 10, Dennis Y Loh
MGI ID: MGI:2664398
Synonyms: CO11.10 TCR-alphabeta, D10, DO.10 Tg, DO11, DO.11, DO-11.10, DO11.10, Do11.10 alphabetaTCR, Do11.10 alphabeta TCR, DO11.10 alphabeta-TCR, DO.11.10 TCR, DO11.10 TCR, DO11.10TCRalphabeta, DO11.10 TCR Tg, DO11 TCR, DO-Tg, OVA-TCRtg, Tg(DO11.10)Tcra/Tcrb, TgN(DO11.10)10Dlo, TgN(DO11.10)10Loh, Tg(TcraDO11.10,TcrbDO11.10)10Dlo
Transgene: Tg(DO11.10)10Dlo  Location: unknown  Genetic Position: Chr18, Syntenic
Alliance: Tg(DO11.10)10Dlo page
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1 x BALB/c
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(DO11.10)10Dlo expresses 2 genes
 
Mutation detailsThis double transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes from the DO11.10 T cell hybridoma encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor. The allele was created by injection of a mix of the two separate transgenes Tg(TcraDO11.10)#Dlo and Tg(TcrbDO11.10)#Dlo into oocytes. (J:25536, J:61321)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Notes

Mice carrying this pair of MHC class II restricted rearranged Tcra and Tcrb T cell receptor transgenes on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment.

References
Original:  J:70572 Murphy KM, et al., Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 1990 Dec 21;250(4988):1720-3
All:  760 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory