Rapgef2^tm1.1Hous
Targeted Allele Detail

Summary

• Symbol: Rapgef2^tm1.1Hous
• Name: Rap guanine nucleotide exchange factor (GEF) 2; targeted mutation 1.1, Steven X Hou
• MGI ID: MGI:4839105
• Synonyms: RapGEF2^cko
• Gene: Rapgef2 Location: Chr3:78969823-79193824 bp, - strand Genetic Position: Chr3, 34.91 cM
• Alliance: Rapgef2^tm1.1Hous page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165879
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 (originally numbered as exon 18) and an FRT and loxP flanked neo cassette was inserted downstream of exon 18. Flp mediated recombination removed the neo cassette leaving exon 18 floxed. (J:165879, J:255838)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rapgef2 Mutation: 82 strains or lines available

References

• Original: J:165879 Satyanarayana A, et al., RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010 Oct 21;116(16):2921-31
• All: 3 reference(s)