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Rapgef2 Gene Detail
Summary
  • Symbol
    Rapgef2
  • Name
    Rap guanine nucleotide exchange factor (GEF) 2
  • Synonyms
    5830453M24Rik, CNRasGEF, mKIAA0313, nRapGEP, Pdzgef1, RA-GEF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2659071
    NCBI Gene: 76089
  • Alliance
    genome feature page
  • Transcription Start Sites
    75 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:78969823-79193824 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6001 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2659071
 protein coding gene Chr3:78969818-79194681 (-)
129S1/SvImJ ENSMUSG00200018711
 protein coding gene Chr3:75747127-75973988 (-)
A/J ENSMUSG00195011550
 protein coding gene Chr3:75811703-76036759 (-)
AKR/J ENSMUSG00220001474
 protein coding gene Chr3:75824271-76049970 (-)
BALB/cJ ENSMUSG00180001804
 protein coding gene Chr3:75903058-76128750 (-)
C3H/HeJ ENSMUSG00175007236
 protein coding gene Chr3:75749883-75974918 (-)
C57BL/6NJ ENSMUSG00215001987
 protein coding gene Chr3:76201949-76425987 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025082
 protein coding gene Chr3:71811787-72038095 (-)
CAST/EiJ ENSTCUG00005001604
 protein coding gene Chr3:75304789-75530449 (-)
CBA/J ENSMUSG00210025628
 protein coding gene Chr3:75832344-76057369 (-)
DBA/2J ENSMUSG00185012452
 protein coding gene Chr3:75987806-76213490 (-)
FVB/NJ ENSMUSG00205006016
 protein coding gene Chr3:74845028-75070094 (-)
JF1/MsJ ENSUMUG00000000930
 protein coding gene Chr3:75570319-75791537 (-)
LP/J ENSMUSG00230008689
 protein coding gene Chr3:78001841-78228678 (-)
NOD/ShiLtJ ENSMUSG00190002483
 protein coding gene Chr3:76322868-76547909 (-)
NZO/HlLtJ ENSMUSG00225004394
 protein coding gene Chr3:80716864-80943704 (-)
PWK/PhJ ENSLUMG00010006227
 protein coding gene Chr3:75641782-75867471 (-)
SPRET/EiJ ENSMSPG00010016960
 protein coding gene Chr3:76340125-76573040 (-)
WSB/EiJ ENSIUOG00005003017
 protein coding gene Chr3:76234161-76459843 (-)



Homology
more
  • Human Ortholog
    RAPGEF2, Rap guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAPGEF2, Rap guanine nucleotide exchange factor 2
  • Synonyms
    CNrasGEF, nRap GEP, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RAGEF, RA-GEF-1, Rap-GEP
  • Links
    NCBI Gene ID: 9693
    UniProt: Q9Y4G8

  • Chr Location
    4q32.1; chr4:159103013-159360174 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RAPGEF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 6 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die at mid-gestation exhibiting growth arrest and defects in vascular development, neural tube closure and embryo turning. Homozygotes for another null allele show yolk sac vascular defects, impaired cell physiology and heart, primitive gut, liver and brain formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    161
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062232 Ensembl Gene Model | MGI Sequence Detail 224002 C57BL/6J ±  kb
    transcript ENSMUST00000195708 Ensembl | MGI Sequence Detail 6964 Not Applicable  
    polypeptide ENSMUSP00000141542 Ensembl | MGI Sequence Detail 1644 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013727 Rap guanine nucleotide exchange factor 2
      (term hierarchy)
    • InterPro Domains
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
      IPR014710 PpnP-like, jelly roll fold
      IPR000159 Ras-associating domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q8CHG7 11 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923339
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 15
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:383232 Zhang HY, et al., Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors. J Neurochem. 2026 Apr;170(4):e70374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory