About   Help   FAQ
Dicer1tm1Bdh
Targeted Allele Detail
Summary
Symbol: Dicer1tm1Bdh
Name: dicer 1, ribonuclease type III; targeted mutation 1, Brian D Harfe
MGI ID: MGI:3589208
Synonyms: Dcrflox, Dcrfx, Dicer1fl, dicerfl, Dicerflox, Dicerlox
Gene: Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance: Dicer1tm1Bdh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100475
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert loxP sites around the exon that encodes most of the second RNaseIII domain as well as an frt-flanked neo within the loxP-encompassed sequence. Cre-mediated removal of the sequence would result in the loss of 90 amino acids, a loss that does not create a downstream frame-shift or an unstable protein. (J:100475)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 351 assay results
22 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 63 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Dicer1tm1Bdh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  93 strains or lines available
References
Original:  J:100475 Harfe BD, et al., The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10898-903
All:  232 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory