Plcg1^tm1Rwen
Targeted Allele Detail

Summary

• Symbol: Plcg1^tm1Rwen
• Name: phospholipase C, gamma 1; targeted mutation 1, Renren Wen
• MGI ID: MGI:4437826
• Synonyms: PLCgamma^fl
• Gene: Plcg1 Location: Chr2:160573230-160617680 bp, + strand Genetic Position: Chr2, 80.97 cM
• Alliance: Plcg1^tm1Rwen page

Plcg1^tm1Rwen/Plcg1^tm1Gcrp Tg(Cd4-cre)1Cwi/0 mice develop inflammatory/autoimmune disease

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette with a 3' loxP site was inserted downstream of exon 4. (J:157757)

Generation of the Plcg1^tm1Rwen allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg1 Mutation: 48 strains or lines available

References

• Original: J:157757 Fu G, et al., Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med. 2010 Feb 15;207(2):309-18
• All: 7 reference(s)