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Plcg1 Gene Detail
Summary
  • Symbol
    Plcg1
  • Name
    phospholipase C, gamma 1
  • Synonyms
    Cded, Plc-1, Plcg-1, Plc-gamma1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97615
    NCBI Gene: 18803
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:160573230-160617680 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 80.97 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97615
protein coding gene Chr2:160573220-160617680 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026806
protein coding gene Chr2:165932388-165976874 (+)
A/J MGP_AJ_G0026772
protein coding gene Chr2:159261722-159306369 (+)
AKR/J MGP_AKRJ_G0026743
protein coding gene Chr2:163974225-164018663 (+)
BALB/cJ MGP_BALBcJ_G0026781
protein coding gene Chr2:159576892-159621351 (+)
C3H/HeJ MGP_C3HHeJ_G0026523
protein coding gene Chr2:164299787-164344429 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027230
protein coding gene Chr2:170844863-170890942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024600
protein coding gene Chr2:152634888-152679467 (+)
CAST/EiJ MGP_CASTEiJ_G0025985
protein coding gene Chr2:164674513-164734692 (+)
CBA/J MGP_CBAJ_G0026500
protein coding gene Chr2:176970715-177015156 (+)
DBA/2J MGP_DBA2J_G0026638
protein coding gene Chr2:158446673-158491153 (+)
FVB/NJ MGP_FVBNJ_G0026605
protein coding gene Chr2:156844581-156889291 (+)
LP/J MGP_LPJ_G0026741
protein coding gene Chr2:166038589-166083082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026626
protein coding gene Chr2:180692944-180739242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027286
protein coding gene Chr2:163809175-163853584 (+)
PWK/PhJ MGP_PWKPhJ_G0025719
protein coding gene Chr2:157993927-158039372 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025522
protein coding gene Chr2:162699114-162743312 (+)
WSB/EiJ MGP_WSBEiJ_G0026055
protein coding gene Chr2:164705821-164750249 (+)



Homology
more
  • Human Ortholog
    PLCG1, phospholipase C gamma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCG1, phospholipase C gamma 1
  • Synonyms
    IDAA, NCKAP3, PLC1, PLC148, PLCgamma1, PLC-II
  • Links
    NCBI Gene ID: 5335
    neXtProt AC: NX_P19174
    UniProt: P19174

  • Chr Location
    20q12; chr20:41136960-41196801 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human PLCG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality associated with arrested growth and/or abnormal hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18803 NCBI Gene Model | MGI Sequence Detail 44451 C57BL/6J ±  kb
    transcript NM_021280 RefSeq | MGI Sequence Detail 4435 ZRU/MplStud  
    polypeptide Q62077 UniProt | EBI | MGI Sequence Detail 1302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 8
      cDNA 18
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13350, MGD-MRK-13353, MGD-MRK-13355, MGI:1329022, MGI:2139113
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 24
      Gene Ontology 25
      Phenotypes 27
    • Earliest
      J:27510 Reith AD, et al., Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991 Sep;10(9):2451-9
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory