Plcg1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plcg1
phospholipase C, gamma 1
MGI:97615

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Plcg1^tm1Gcrp/Plcg1^tm1Rwen Tg(Cd4-cre)1Cwi/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive T cell differentiation	J:157757
	abnormal CD8-positive, alpha-beta T cell differentiation	J:157757
	abnormal regulatory T cell physiology	J:157757
	abnormal T cell activation	J:157757
	alopecia	J:157757
	decreased body weight	J:157757
	decreased CD4-positive, alpha-beta T cell number	J:157757
	decreased CD8-positive, alpha-beta T cell number	J:157757
	decreased interferon-gamma secretion	J:157757
	decreased interleukin-2 secretion	J:157757
	decreased single-positive T cell number	J:157757
	decreased T cell number	J:157757
	decreased T cell proliferation	J:157757
	dermatitis	J:157757
	increased double-positive T cell number	J:157757
	increased T cell apoptosis	J:157757
	rectal prolapse	J:157757
Plcg1^tm1Gcrp/Plcg1^tm1Rwen Tg(Cd4-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:157757
	decreased double-negative T cell number	J:157757
	increased CD8-positive, alpha-beta T cell number	J:157757
	increased double-positive T cell number	J:157757
	thymus hyperplasia	J:157757

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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