Egr3^tm1.1Kfuji
Targeted Allele Detail

Summary

• Symbol: Egr3^tm1.1Kfuji
• Name: early growth response 3; targeted mutation 1.1, Keishi Fujio
• MGI ID: MGI:5548115
• Synonyms: Egr-3 flox
• Gene: Egr3 Location: Chr14:70314766-70320062 bp, + strand Genetic Position: Chr14, 36.2 cM, cytoband D1
• Alliance: Egr3^tm1.1Kfuji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205814
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:205814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr3 Mutation: 20 strains or lines available

References

• Original: J:205814 Sumitomo S, et al., Transcription factor early growth response 3 is associated with the TGF-beta1 expression and the regulatory activity of CD4-positive T cells in vivo. J Immunol. 2013 Sep 1;191(5):2351-9
• All: 3 reference(s)