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Cd19tm1(cre)Cgn
Targeted Allele Detail
Summary
Symbol: Cd19tm1(cre)Cgn
Name: CD19 antigen; targeted mutation 1, University of Cologne
MGI ID: MGI:1931143
Synonyms: B-Cre, CD19-, Cd19cre, Cd19Cre, CD19-Cre, CD19-KO
Gene: Cd19  Location: Chr7:126007622-126014061 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
Alliance: Cd19tm1(cre)Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27463
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Cd19tm1(cre)Cgn expression driven by 1 gene
 
Mutation detailsIn-frame insertion of a cre recombinase gene into the first coding exon followed by an fFRT site flanked neomycin resistance gene cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. (J:27463)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd19 (mouse)
Summary of all recombinase alleles driven by Cd19.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cd19tm1(cre)Cgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd19 Mutation:  57 strains or lines available
References
Original:  J:27463 Rickert RC, et al., Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature. 1995 Jul 27;376(6538):352-5
All:  709 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory