Dtx1^tm1.1Mzl
Targeted Allele Detail

Summary

• Symbol: Dtx1^tm1.1Mzl
• Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1.1, Ming-Zong Lai
• MGI ID: MGI:4355028
• Synonyms: Dtx1^fldeltaneo
• Gene: Dtx1 Location: Chr5:120818267-120849992 bp, - strand Genetic Position: Chr5, 60.64 cM
• Alliance: Dtx1^tm1.1Mzl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151605
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A Frt-flanked neomycin cassette and a loxP site were placed downstream of exon 3. An additional loxP site was placed upstream of exon 3. The neomycin cassette was deleted from the germline by crossing founder mice with ACT-FLPe transgenic mice. (J:151605)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtx1 Mutation: 35 strains or lines available

References

• Original: J:151605 Hsiao HW, et al., Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. Immunity. 2009 Jul 17;31(1):72-83
• All: 2 reference(s)