Phenotypes associated with this allele

• Allele Symbol: Dtx1^tm1.1Mzl
• Allele Name: targeted mutation 1.1, Ming-Zong Lai
• Allele ID: MGI:4355028
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dtx1^tm1.1Mzl/Dtx1^tm1.1Mzl Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4355050

Genotype
MGI:4355050

cn1

• Allelic Composition: Dtx1^tm1.1Mzl/Dtx1^tm1.1Mzl; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

increased interleukin-2 secretion ( J:151605 )

• thymocytes and T cells secrete more IL-2 after activation relative to controls

increased autoantibody level ( J:151605 )

• increased levels of rheumatoid factor are detected in the sera of older mice

increased anti-double stranded DNA antibody level ( J:151605 )

• increased levels of anti-DNA antibodies are detected in the sera of older mice

increased anti-histone antibody level ( J:151605 )

• increased levels of anti-histone antibodies are detected in the sera of older mice

hematopoietic system

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

endocrine/exocrine glands

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

cellular

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation