Tcf12^tm3Zhu
Targeted Allele Detail

Summary

• Symbol: Tcf12^tm3Zhu
• Name: transcription factor 12; targeted mutation 3, Yuan Zhuang
• MGI ID: MGI:3769702
• Synonyms: HEB^flox, Tcf12^f
• Gene: Tcf12 Location: Chr9:71751534-72019611 bp, - strand Genetic Position: Chr9, 39.85 cM
• Alliance: Tcf12^tm3Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 18 and an additional loxP site was inserted into intron 17. The neo cassette was removed by cre-mediated recombination using a transiently expressing cre vector leaving a floxed exon 18. (J:129570)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcf12 Mutation: 74 strains or lines available

References

• Original: J:129570 Wojciechowski J, et al., E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J Immunol. 2007 May 1;178(9):5717-26
• All: 26 reference(s)