Il10ra^tm1.1Jack
Targeted Allele Detail

Summary

• Symbol: Il10ra^tm1.1Jack
• Name: interleukin 10 receptor, alpha; targeted mutation 1.1, Robert S Jack
• MGI ID: MGI:4437317
• Synonyms: Il10r1fl, Il10ra^fl, IL-10R^Fl, Il10r^{tm1(flox)Greifswald}
• Gene: Il10ra Location: Chr9:45165135-45180447 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Il10ra^tm1.1Jack page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157787
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:157787)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il10ra Mutation: 32 strains or lines available

References

• Original: J:157787 Pils MC, et al., Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol. 2010 Feb;40(2):443-8
• All: 20 reference(s)