Birc5^tm1Wnt
Targeted Allele Detail

Summary

• Symbol: Birc5^tm1Wnt
• Name: baculoviral IAP repeat-containing 5; targeted mutation 1, Astar Winoto
• MGI ID: MGI:3028474
• Synonyms: S^fl, survivin^flox
• Gene: Birc5 Location: Chr11:117740077-117746569 bp, + strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Birc5^tm1Wnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87435
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neomycin cassette was placed downstream of exon 4. The neomycin gene was subsequently excised from properly targeted ES cells by transient transfection with a cre expressing plasmid. This resulted in all four exons being flanked by two loxP sites. (J:87435)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Birc5^tm1Wnt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc5 Mutation: 19 strains or lines available

References

• Original: J:87435 Xing Z, et al., Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. J Exp Med. 2004 Jan 5;199(1):69-80
• All: 20 reference(s)