About   Help   FAQ
Birc5 Gene Detail
Summary
  • Symbol
    Birc5
  • Name
    baculoviral IAP repeat-containing 5
  • Synonyms
    Api4, survivin, TIAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203517
    NCBI Gene: 11799
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117740077-117746569 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203517
protein coding gene Chr11:117740063-117746569 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019456
protein coding gene Chr11:122133369-122140724 (+)
A/J MGP_AJ_G0019424
protein coding gene Chr11:116721794-116729604 (+)
AKR/J MGP_AKRJ_G0019394
protein coding gene Chr11:120275520-120282014 (+)
BALB/cJ MGP_BALBcJ_G0019399
protein coding gene Chr11:117092389-117098872 (+)
C3H/HeJ MGP_C3HHeJ_G0019205
protein coding gene Chr11:120559564-120568256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019848
protein coding gene Chr11:125859166-125865706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017473
protein coding gene Chr11:113729491-113734791 (+)
CAST/EiJ MGP_CASTEiJ_G0018759
protein coding gene Chr11:121982465-121988883 (+)
CBA/J MGP_CBAJ_G0019176
protein coding gene Chr11:130815114-130821592 (+)
DBA/2J MGP_DBA2J_G0019288
protein coding gene Chr11:116122196-116128732 (+)
FVB/NJ MGP_FVBNJ_G0019280
protein coding gene Chr11:115741374-115748643 (+)
LP/J MGP_LPJ_G0019358
protein coding gene Chr11:122457370-122465034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019313
protein coding gene Chr11:129773324-129780647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019887
protein coding gene Chr11:120926299-120932788 (+)
PWK/PhJ MGP_PWKPhJ_G0018525
protein coding gene Chr11:117479519-117486855 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018317
protein coding gene Chr11:120655128-120661372 (+)
WSB/EiJ MGP_WSBEiJ_G0018811
protein coding gene Chr11:120889964-120896459 (+)



Homology
more
  • Human Ortholog
    BIRC5, baculoviral IAP repeat containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC5, baculoviral IAP repeat containing 5
  • Synonyms
    API4, EPR-1
  • Links
    NCBI Gene ID: 332
    neXtProt AC: NX_O15392
    UniProt: O15392

  • Chr Location
    17q25.3; chr17:78214186-78225636 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human BIRC5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die during early embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017716 Ensembl Gene Model | MGI Sequence Detail 6493 C57BL/6J ±  kb
    transcript ENSMUST00000081387 Ensembl | MGI Sequence Detail 947 Not Applicable  
    polypeptide ENSMUSP00000079124 Ensembl | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 1
      cDNA 98
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196343
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 68
      Gene Ontology 15
      Phenotypes 48
    • Earliest
      J:42738 Tewari M, et al., AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 1997 Sep 15;57(18):4063-9
    • Latest
      J:353335 Grego-Bessa J, et al., Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development. Circ Res. 2023 Nov 10;133(11):927-943

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory