Arl4d^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arl4d^{tm1c(EUCOMM)Wtsi}
• Name: ADP-ribosylation factor-like 4D; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7398103
• Synonyms: Arl4d^fl
• Gene: Arl4d Location: Chr11:101556367-101558658 bp, + strand Genetic Position: Chr11, 65.48 cM
• Alliance: Arl4d^{tm1c(EUCOMM)Wtsi} page
• IMPC: Arl4d gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330548
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 101556890 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 101558944. The critical exon(s) is/are thus flanked by loxP sites. . The lacZ/neomycin cassette was removed via flp-mediated recombination generating a conditional ready (floxed) allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:330548)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arl4d Mutation: 20 strains or lines available

References

• Original: J:330548 Geers B, et al., The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability. Cells. 2022 Aug 25;11(17)
• All: 1 reference(s)