Rc3h1^tm1.1Mass
Targeted Allele Detail

Summary

• Symbol: Rc3h1^tm1.1Mass
• Name: RING CCCH (C3H) domains 1; targeted mutation 1.1, Marc Schmidt-Supprian
• MGI ID: MGI:5301575
• Synonyms: Rc3h1^F
• Gene: Rc3h1 Location: Chr1:160733988-160802548 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Rc3h1^tm1.1Mass page

Increased spleen size in Rc3h1^tm1.1Mass/Rc3h1^tm1.1MassCommd10^{Tg(Vav1-icre)A2Kio}/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177784
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 4 through 6 floxed. (J:177784)

Generation of the conditional Rc3h1^tm1.1Mass allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rc3h1 Mutation: 42 strains or lines available

References

• Original: J:177784 Bertossi A, et al., Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56
• All: 9 reference(s)