Myd88^tm1.1Medz
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1.1Medz
• Name: myeloid differentiation primary response gene 88; targeted mutation 1.1, Ruslan Medzhitov
• MGI ID: MGI:5616077
• Synonyms: Myd88^FL
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1.1Medz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209373
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3-5, encoding the Toll-IL-1 receptor (TIR) domain, were flanked by loxP sites. The frt-flanked neomycin resistance cassette was removed via flp-mediated recombination. When the floxed region is removed via cre-mediated recombination, splicing from exon 2 to exon 6 results in a frameshift mutation. (J:209373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 50 strains or lines available

References

• Original: J:209373 Schenten D, et al., Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity. 2014 Jan 16;40(1):78-90
• All: 5 reference(s)