Bcl11b^tm2.1Jpk
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm2.1Jpk
• Name: B cell leukemia/lymphoma 11B; targeted mutation 2.1, Japan Kominami
• MGI ID: MGI:5571289
• Synonyms: Bcl11b^EX2flox, Bcl11b^F, Bcl11b^flox
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm2.1Jpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210122
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and a Neomycin selection cassette. The Neo cassette was removed by crossing with B6-CAG-FLPe mice. (J:210122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 45 strains or lines available

References

• Original: J:210122 Go R, et al., Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele. Cancer Sci. 2013 Aug;104(8):1009-16
• All: 7 reference(s)