About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl11btm2.1Jpk
targeted mutation 2.1, Japan Kominami
MGI:5571289
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl11btm2.1Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0 		involves: C57BL/6 MGI:5571296
cn2
 		Bcl11btm2.1Jpk/Bcl11b+
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6J * DBA/2 MGI:5571295


Genotype
MGI:5571296
cn1
Allelic
Composition		 Bcl11btm2.1Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11btm2.1Jpk mutation (2 available); any Bcl11b mutation (45 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:210122 )
• increased percentage of immature single positive cells in irradiated mice
decreased thymocyte number ( J:210122 )
• in irradiated mice
increased double-negative T cell number ( J:210122 )
• increased percentage in irradiated mice
decreased double-positive T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD4-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD8-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice

neoplasm
increased lymphoma incidence ( J:210122 )
• thymic lymphomas in 4 of 5 irradiated mice

cellular
abnormal cell cycle ( J:210122 )
• attenuated radiation-induced cell cycle arrest at the S phase in immature single positive cells of irradiated mice

endocrine/exocrine glands
decreased thymocyte number ( J:210122 )
• in irradiated mice

hematopoietic system
abnormal T cell number ( J:210122 )
• increased percentage of immature single positive cells in irradiated mice
decreased thymocyte number ( J:210122 )
• in irradiated mice
increased double-negative T cell number ( J:210122 )
• increased percentage in irradiated mice
decreased double-positive T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD4-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD8-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice




Genotype
MGI:5571295
cn2
Allelic
Composition		 Bcl11btm2.1Jpk/Bcl11b+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11btm2.1Jpk mutation (2 available); any Bcl11b mutation (45 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:210122 )
N
• gamma-irradiated thymus do not exhibit clonal growth of thymocytes or changes in thymocyte numbers or differentiation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory