Tnftm1.1Sned
Targeted Allele Detail
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Symbol: |
Tnftm1.1Sned |
Name: |
tumor necrosis factor; targeted mutation 1.1, Sergei A Nedospasov |
MGI ID: |
MGI:3527143 |
Synonyms: |
TNFflox, Tnftm1Sned |
Gene: |
Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
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Alliance: |
Tnftm1.1Sned page
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Germline Transmission: |
Earliest citation of germline transmission:
J:95684
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A floxed neomycin selection cassette was inserted approximately 1 kb downstream of the gene and a third loxP site was inserted in the 3rd intron. The neomycin resistance cassette was subsequently removed by transient cre expression in ES cells. The remaining loxP sites had no effect on gene expression or phenotype.
(J:95684)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tnf Mutation: |
46 strains or lines available
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Original: |
J:95684 Grivennikov SI, et al., Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity. 2005 Jan;22(1):93-104 |
All: |
27 reference(s) |
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