Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 18, Jody Haigh
• MGI ID: MGI:6195702
• Synonyms: ROSA26-Zeb2^tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263589
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm18(Zeb2)Jhai} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zeb2 (MGI:1344407)

• Mutation details: The targeting vector inserted into the locus contains a floxed PGK-neo STOP cassette, mouse Zeb2 cDNA with an N-terminal FLAG-tag, IRES, and EGFP. (J:263520, J:263589)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:263589 Tatari MN, et al., ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins. Cell Mol Life Sci. 2014 Sep;71(18):3599-609
• All: 9 reference(s)