Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}
• Allele Name: targeted mutation 18, Jody Haigh
• Allele ID: MGI:6195702
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm18(Zeb2)Jhai/Gt(ROSA)26Sor^tm18(Zeb2)Jhai Tg(Tek-cre)1Ywa/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL	MGI:6195747
cn2	Gt(ROSA)26Sor^tm18(Zeb2)Jhai/Gt(ROSA)26Sor^+ Tg(Tek-cre)1Ywa/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL	MGI:6195748
cn3	Gt(ROSA)26Sor^tm18(Zeb2)Jhai/Gt(ROSA)26Sor^tm18(Zeb2)Jhai Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * CD-1 * DBA/2	MGI:6195751
cn4	Gt(ROSA)26Sor^tm18(Zeb2)Jhai/Gt(ROSA)26Sor^tm18(Zeb2)Jhai Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * CD-1 * SJL	MGI:6195746

Genotype
MGI:6195747

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}; Tg(Tek-cre)1Ywa/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 12.7 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (87.5%)

• cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

increased leukemia incidence ( J:263520 )

• thymomas have an immature/early T-cell precursor leukemia signature

• 12.5% of tumors are myeloid leukemia

increased thymoma incidence ( J:263520 )

• thymomas have an immature/early T-cell precursor leukemia signature

• thymic tumors lack mature T-cell markers such as surface CD3 and CD8 and exhibit a higher percentage of cells that express the stem/progenitor marker cKit or CD44

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 12.7 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (87.5%)

• cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

Genotype
MGI:6195748

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor⁺; Tg(Tek-cre)1Ywa/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL

neoplasm

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

Genotype
MGI:6195751

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2

mortality/aging

premature death ( J:263520 )

• mice exhibit about 50% survival at 8-10 months of age

neoplasm

increased T cell acute lymphoblastic leukemia incidence ( J:263520 )

• mice develop T-cell lymphoblastic leukemia, with dense neoplastic infiltrates in the cranial mediastinum characterized by medium to large-sized atypical lymphoid cells with numerous mitotic figures and dissemination to the heart

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell adult acute lymphocytic leukemia		DOID:5602		J:263520

Genotype
MGI:6195746

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * CD-1 * SJL

mortality/aging

premature death ( J:263520 )

• mice start to die from 5 months of age onwards, with 53% of mice dying by 15 months

neoplasm

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

increased T cell acute lymphoblastic leukemia incidence ( J:263520 )

• mice exhibit precursor T-cell lymphoblastic leukemia (CD45/CLA+; CD3+; CD45/B220- and IBA-1- with presence of cKit+ cells)

• the pre T-cell lymphoblastic leukemia likely originates from the thymus with sheets of medium to large-size lymphoid cells infiltrating into surrounding tissues, including lung, heart, and cranial mediastinum and systematically into lymph nodes, liver, spleen, kidney and bone marrow

endocrine/exocrine glands

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell adult acute lymphocytic leukemia		DOID:5602		J:263520