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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Wnt1-cre)11Rth
transgene insertion 11, David H Rowitch
MGI:2386570
Summary 175 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ext1tm1Yama/Ext1tm1Yama
Tg(Wnt1-cre)11Rth/0
B6.Cg-Ext1tm1Yama Tg(Wnt1-cre)11Rth MGI:4360747
cn2
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Tg(Wnt1-cre)11Rth/0
B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor Tg(Wnt1-cre)11Rth MGI:3852467
cn3
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Tg(Wnt1-cre)11Rth/0
B6.Cg-Ptpn11tm1.1Rbns Tg(Wnt1-cre)11Rth MGI:3852466
cn4
Ext1tm1Yama/Ext1+
Tg(Wnt1-cre)11Rth/0
Tgfb2tm1Doe/Tgfb2+
B6.Cg-Tgfb2tm1Doe Ext1tm1Yama Tg(Wnt1-cre)11Rth MGI:4360749
cn5
Chd7Gt(XK403)Byg/Chd7+
Tg(Wnt1-cre)11Rth/0
either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1) MGI:4410359
cn6
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1) MGI:3611573
cn7
Tbx1tm2.1Bem/Tbx1tm2.1Bem
Tg(Wnt1-cre)11Rth/0
either: (involves: 129/Sv * C57BL/6 * C57BL/6J * CBA/J * SJL) or (involves: 129/Sv * C57BL/6J * CBA/J * CD-1 * SJL) MGI:4410368
cn8
Lmo4tm1Sho/Lmo4tm1Sho
Tg(Wnt1-cre)11Rth/0
either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6) MGI:3035941
cn9
Mrgprdtm1Mjz/?
Rettm1Ddg/Rettm1Ddg
Tg(Wnt1-cre)11Rth/0
involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J MGI:4413446
cn10
Mfn2tm1Dcc/Mfn2tm3Dcc
Tg(Wnt1-cre)11Rth/0
involves: 129 * 129S4/SvJaeSor * Black Swiss MGI:3779094
cn11
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm2.1Weg/Sox11tm2.1Weg
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:5285375
cn12
Rettm1Ddg/Rettm1Ddg
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:4413445
cn13
Hdac2tm1.1Eno/Hdac2tm1.1Eno
Tg(Wnt1-cre)11Rth/?
involves: 129 * C57BL/6 * CBA MGI:3851919
cn14
Hdac1tm1.1Eno/Hdac1tm1.1Eno
Tg(Wnt1-cre)11Rth/?
involves: 129 * C57BL/6 * CBA MGI:3851918
cn15
Hdac8tm1.1Eno/Y
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA * CD-1 MGI:3851920
cn16
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308955
cn17
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308958
cn18
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308956
cn19
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308953
cn20
Dicer1tm1Bdh/Dicer1+
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:4868201
cn21
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:4868120
cn22
Cited2tm1Bha/Cited2tm2Bha
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA * SJL MGI:3804086
cn23
Hs2st1tm1.1Je/Hs2st1tm1.1Je
Hs6st1tm1Wvc/Hs6st1tm1Wvc
Hs6st2tm1Lex/Hs6st2tm1Lex
Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6J * CBA/J MGI:5430387
cn24
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm3Spe
Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J MGI:5702481
cn25
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5702479
cn26
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J MGI:5305927
cn27
Nrg1tm4Cbm/Nrg1tm4.1Cbm
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J MGI:5524256
cn28
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J MGI:4365544
cn29
Gja1tm1Kwi/Gja1tm1Kwi
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3653215
cn30
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3811608
cn31
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:5659950
cn32
Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:3697616
cn33
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:5707466
cn34
Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:4438212
cn35
Pitx2tm1.1Sac/Pitx2tm2Sac
Tg(Wnt1-cre)11Rth/?
Gt(ROSA)26Sortm1Sor/?
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5298219
cn36
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5447985
cn37
Fgf15tm1Sms/Fgf15tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:3639491
cn38
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J MGI:5440182
cn39
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J MGI:5440183
cn40
Hand2tm1Cse/Hand2tm1Cse
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:3715254
cn41
Hand2tm1Cse/Hand2tm1Dsr
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:3848967
cn42
Nf1tm1Par/Nf1tm1Par
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3710237
cn43
Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Wnt1-cre)11Rth/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3711498
cn44
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3702775
cn45
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3623411
cn46
Gata6tm2Msp/Gata6tm2Msp
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3623951
cn47
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm2Sev/Isl1tm2Sev
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3817490
cn48
Acvr1tm1Vk/Acvr1tm1.1Vk
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3697607
cn49
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3804318
cn50
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3804321
cn51
Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Pax6-cre,GFP)1Pgr/?
Tg(Wnt1-cre)11Rth/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB MGI:3711516
cn52
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR MGI:3703442
cn53
Fgfr1tm2Jrt/Fgfr1tm2Jrt
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR MGI:3703441
cn54
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR MGI:3703447
cn55
Ednrbtm1Nrd/Ednrbtm1Nrd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J MGI:3814191
cn56
Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5660196
cn57
Kif3atm2Gsn/Kif3atm2Gsn
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:4443124
cn58
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5659973
cn59
Pax3tm2Joe/Pax3tm2Joe
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:4442469
cn60
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5659974
cn61
Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3tm1Gela
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5660197
cn62
Ndst1tm1Grob/Ndst1tm1Grob
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:4943277
cn63
Mapk1tm1Gela/Mapk1tm1Gela
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5660194
cn64
Ndst1tm1Grob/Ndst1tm1Grob
Ndst2tm1Lkj/Ndst2tm1Lkj
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5430386
cn65
Jag1tm2Grid/Jag1tm2Grid
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:5318528
cn66
Zfpm2tm1Sho/Zfpm2tm2Sho
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3851405
cn67
Snai1tm1Grid/Snai1tm2Grid
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3715215
cn68
Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3715216
cn69
Hand2tm1Cse/Hand2+
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6J * CBA/J MGI:4417976
cn70
Hand2tm1.1Majh/Hand2tm1.1Majh
Tg(Wnt1-cre)11Rth/0
involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2 MGI:3804452
cn71
Nfatc1tm1Glm/Nfatc1tm1Glm
Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * CBA MGI:5432553
cn72
Nipbltm1.1Hpt/Nipbltm1.1Hpt
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL MGI:5698653
cn73
Mau2tm1.1Hpt/Mau2tm1.1Hpt
Nipbltm1.1Hpt/Nipbl+
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL MGI:5698689
cn74
Mau2tm1.1Hpt/Mau2tm1.1Hpt
Nipbltm1.1Hpt/Nipbltm1.1Hpt
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL MGI:5698685
cn75
Mau2tm1.1Hpt/Mau2tm1.1Hpt
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL MGI:5698674
cn76
Bdnftm1Krj/Bdnftm1Lfr
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * CBA MGI:3584263
cn77
Pax9tm1.1Hpt/Pax9tm1.1Hpt
Tg(Wnt1-cre)11Rth/?
involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:3723641
cn78
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6J * CBA/J MGI:4438210
cn79
Phox2atm2Jbr/Phox2atm2Jbr
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6J * CBA/J MGI:4438209
cn80
Ngfrtm1.1Vk/Ngfrtm1.1Vk
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6J * CBA/J * FVB/N MGI:5301302
cn81
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5491198
cn82
Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae *129X1/SvJ * C57BL/6 * CBA * Swiss Webster MGI:4839958
cn83
Flnatm1.1Caw/Y
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3699953
cn84
Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Tg(CAG-cat-lacZ)11Miya/0
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2 MGI:5485200
cn85
Ror1tm1.1Meg/Ror1tm1.1Meg
Ror2tm1.1Meg/Ror2tm1.1Meg
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:5315491
cn86
Bmpr2tm1.1Enl/Bmpr2tm1.2Enl
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:5558941
cn87
Gt(ROSA)26Sortm1Sor/?
Myctm2Fwa/Myctm2Fwa
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA MGI:3720325
cn88
Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J MGI:5430383
cn89
Krastm4Tyj/Krastm4Tyj
Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J MGI:5430385
cn90
Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
Tg(Pax6-HRAS*G12V)2044Ove/0
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5430384
cn91
Pomt2tm1.1Hhu/Pomt2tm1.1Hhu
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5302859
cn92
Zic3tm2.1Jwb/Y
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6J * CBA/J MGI:5470170
cn93
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J MGI:4843924
cn94
Efnb1tm1Sor/Efnb1+
Tg(Wnt1-cre)11Rth/?
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:3719104
cn95
Arid1atm1.1Mag/Arid1atm1.1Mag
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5784731
cn96
Adam22tm1.1Mejr/Adam22tm1.1Mejr
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:4441314
cn97
Lgi4tm1.1Jrb/Lgi4tm1.1Jrb
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:4441318
cn98
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312863
cn99
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312864
cn100
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312865
cn101
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312866
cn102
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312867
cn103
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312868
cn104
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312869
cn105
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312870
cn106
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312871
cn107
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312873
cn108
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312874
cn109
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312875
cn110
Tg(Wnt1-cre)11Rth/0
Wnt5atm1Amc/Wnt5atm1.1Krvl
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J MGI:5605991
cn111
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3623395
cn112
Myctm2Fwa/Myctm2Fwa
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3720189
cn113
Myctm2Fwa/Myc+
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3720194
cn114
Foxd3tm2Lby/Foxd3tm3Lby
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3806465
cn115
Zfpm1tm4Sho/Zfpm1tm4Sho
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3586444
cn116
Ptpn11tm6Bgn/Ptpn11+
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6 * CBA/J MGI:3840256
cn117
Srftm1Rmn/Srftm1Rmn
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5659953
cn118
Wlstm1.1Whsu/Wlstm1.1Whsu
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:4881721
cn119
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Tg(Wnt1-cre)11Rth/?
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5702482
cn120
Megf8tm1.2Ddg/Megf8tm1.2Ddg
Tg(Wnt1-cre)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5558940
cn121
Hprttm2(Pgk1-Pac/TK)Brd/Hprt+
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3772559
cn122
Hprttm2(Pgk1-Pac/TK)Brd/Y
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3772558
cn123
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3697386
cn124
Lmx1btm1Rjo/Lmx1btm1Witz
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4818571
cn125
Hoxa3tm1Mrc/Hoxa3tm3.1Nrm
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4461312
cn126
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Wnt1-cre)11Rth/0
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:5490240
cn127
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S/Sv * Black Swiss * C57BL/6J * CBA/J MGI:3831922
cn128
Dph1tm2Bhr/Dph1tm2Bhr
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J MGI:5659977
cn129
Dph1tm2Bhr/Dph1+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J MGI:5659976
cn130
Plxnd1tm1.1Tmj/Plxnd1tm1.1Tmj
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA/J MGI:3848822
cn131
Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA/J MGI:3848832
cn132
Sox9tm2Crm/Sox9+
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:3718125
cn133
Sox9tm2Crm/Sox9tm2Crm
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:3718120
cn134
Wlstm1.1Lan/Wlstm1.1Lan
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * C57BL/6J * CBA/J * SJL MGI:4838405
cn135
Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6 * CBA MGI:3835760
cn136
Nf1tm1Par/Nf1tm1Tyj
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6 * CBA MGI:3776056
cn137
Myocdtm1Msp/Myocdtm1Msp
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6 * CBA MGI:3797650
cn138
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * CBA MGI:2674120
cn139
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J MGI:4440902
cn140
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J MGI:5312862
cn141
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J MGI:4415143
cn142
Gja1tm1Gfi/Gja1tm1Gfi
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J * FVB/N MGI:3652904
cn143
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J * SJL MGI:5659952
cn144
Rarbtm2Ipc/Rarbtm2Ipc
Rargtm3Ipc/Rargtm3Ipc
Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL MGI:3620540
cn145
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3773283
cn146
Notch1tm2Rko/Notch1tm2Rko
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:5318530
cn147
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4843925
cn148
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4843923
cn149
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4943276
cn150
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
Tg(Wnt1-cre)11Rth/?
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:3716199
cn151
Hmx1tm1.1Arte/Hmx1tm1.1Arte
Tg(Wnt1-cre)11Rth/0
involves: BALB/c * C57BL/6J * CBA/J MGI:5515738
cn152
Tg(CAG-Otx2,-EGFP)1Eno/?
Tg(Wnt1-cre)11Rth/?
involves: C3H * C57BL/6 MGI:3851922
cn153
Tg(Wnt1-cre)11Rth/?
Tg(CAG-Lhx,-EGFP)1Eno/?
involves: C3H * C57BL/6 MGI:3851921
cn154
Hoxa3tm2Nrm/Hoxa3tm3.1Nrm
Tg(Wnt1-cre)11Rth/0
involves: C3H * C57BL/6 * CBA/J MGI:4461313
cn155
Pdgfratm8Sor/Pdgfratm8Sor
Tg(Wnt1-cre)11Rth/?
involves: C57BL/6 * CBA MGI:3715094
cn156
Pdgfratm8Sor/Pdgfratm8Sor
Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
Tg(Wnt1-cre)11Rth/?
involves: C57BL/6 * CBA MGI:3715096
cn157
Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
Tg(Wnt1-cre)11Rth/?
involves: C57BL/6 * CBA MGI:3715095
cn158
Ikbkaptm1c(KOMP)Wtsi/Ikbkaptm1c(KOMP)Wtsi
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * C57BL/6N * CBA/J MGI:5558037
cn159
Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5444486
cn160
Arid1atm1.1Mag/Arid1a+
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5784729
cn161
Map3k7tm1Mis/Map3k7tm1Mis
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5514176
cn162
Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J MGI:5495316
cn163
Arid1atm1.1Mag/Arid1atm1.1Mag
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5784730
cn164
Rhoatm1Yuyo/Rhoatm1Yuyo
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5004977
cn165
Smotm1Amc/Smotm2Amc
Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J MGI:3716198
cn166
Zic3tm1.1Smwa/Y
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5476842
cn167
Ednratm2Ywa/Ednratm2Ywa
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:3849287
cn168
Gt(ROSA)26Sortm5(Wnt5a)Flng/?
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J MGI:5613589
cn169
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J * FVB/N MGI:4361520
cn170
Hoxb1tm5Mrc/Hoxb1tm7Mrc
Tg(Wnt1-cre)11Rth/0
Not Specified MGI:3050407
cn171
Tfap2atm1Hsv/Tfap2atm2Will
Tg(Wnt1-cre)11Rth/0
Not Specified MGI:3038354
cn172
Pdgfratm8Sor/Pdgfratm8Sor
Tg(Wnt1-cre)11Rth/0
Not Specified MGI:2450742
cx173
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Msx2tm1Rilm/Msx2tm1Rilm
Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:5427701
cx174
Plxnd1tm1.1Tmj/Plxnd1+
Plxnd1tm1Ddg/Plxnd1+
Tg(Wnt1-cre)11Rth/0
involves: 129S/SvEv * C57BL/6J * CBA/J MGI:5550533
cx175
Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: C57BL/6J * CBA/J * Swiss albino MGI:5551395


Genotype
MGI:4360747
cn1
Allelic
Composition
Ext1tm1Yama/Ext1tm1Yama
Tg(Wnt1-cre)11Rth/0
Genetic
Background
B6.Cg-Ext1tm1Yama Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (33 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die within the first day of birth

vision/eye
• mice exhibit eye morphology defects
• however, lens thickness is normal
• 58% of mutant mice exhibit ciliary body coloboma
• at E18.5, 99% of mutant mice exhibit ventral iris coloboma
• the corneal stroma lacks collagen staining unlike in wild-type mice

craniofacial

hearing/vestibular/ear

embryo
• at E15.5, neural crest cell proliferation is reduced compared to in wild-type mice
• however, neural crest cell migration into the periocular mesenchyme at E11.5 and levels of apoptosis are normal

digestive/alimentary system

cellular
• at E15.5, neural crest cell proliferation is reduced compared to in wild-type mice
• however, neural crest cell migration into the periocular mesenchyme at E11.5 and levels of apoptosis are normal

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Peters Anomaly 604229 J:152572




Genotype
MGI:3852467
cn2
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Tg(Wnt1-cre)11Rth/0
Genetic
Background
B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Ptpn11tm1.1Rbns mutation (0 available); any Ptpn11 mutation (25 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

nervous system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

cardiovascular system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal




Genotype
MGI:3852466
cn3
Allelic
Composition
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Tg(Wnt1-cre)11Rth/0
Genetic
Background
B6.Cg-Ptpn11tm1.1Rbns Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1.1Rbns mutation (0 available); any Ptpn11 mutation (25 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryo survival drops after E15.5 and no mice are born alive

craniofacial
• neural crest cell-derived mandible is dramatically ablated or completely absent
• neural crest cell-derived craniofacial bones are dramatically ablated or completely absent
• neural crest cell-derived nasal cartilage is dramatically ablated or completely absent
• small nose

cardiovascular system
• abnormal arch arteries are observed in 32% with 5 of 19 mice exhibiting malpositioning of the left carotid artery and 1 of 19 exhibiting defective left carotid artery
• mice exhibit a truncal valve containing 3 leaflets (in 90% of mice) or 4 leaflets (in 10% of mice) unlike in wild-type mice
• the truncal valve is longer and thicker than the aortic valves of wild-type mice
• however, the atrioventricular valves are normal
• all mice exhibit persistent truncus arteriosus
• 84% of heart have type II and 16% type I persistent truncus arteriosus

growth/size/body
• neural crest cell-derived nasal cartilage is dramatically ablated or completely absent
• small nose

hearing/vestibular/ear

respiratory system
• neural crest cell-derived nasal cartilage is dramatically ablated or completely absent

skeleton
• neural crest cell-derived mandible is dramatically ablated or completely absent
• neural crest cell-derived craniofacial bones are dramatically ablated or completely absent
• neural crest cell-derived nasal cartilage is dramatically ablated or completely absent

vision/eye

digestive/alimentary system




Genotype
MGI:4360749
cn4
Allelic
Composition
Ext1tm1Yama/Ext1+
Tg(Wnt1-cre)11Rth/0
Tgfb2tm1Doe/Tgfb2+
Genetic
Background
B6.Cg-Tgfb2tm1Doe Ext1tm1Yama Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (33 available)
Tgfb2tm1Doe mutation (1 available); any Tgfb2 mutation (9 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive into adulthood

vision/eye
• mice exhibit defects in components of the aqueous drainage system
• however, the iridocorneal angle is normal
• the trabecular beam contains fewer cells than in wild-type mice
• mice exhibit ocular hypertension unlike single heterozygotes




Genotype
MGI:4410359
cn5
Allelic
Composition
Chd7Gt(XK403)Byg/Chd7+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation (0 available); any Chd7 mutation (71 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system

craniofacial

embryo




Genotype
MGI:3611573
cn6
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E9.5 and E10.5, the cranial neural tube is open dorsally
• at E9.5 and E10.5, the isthmus (the constriction of the neural tube at the midbrain hindbrain boundary) is absent
• at E9.5 and E10.5 the brain rostral to the otic vesicle is significantly smaller

embryo
• at E9.5 and E10.5, the cranial neural tube is open dorsally




Genotype
MGI:4410368
cn7
Allelic
Composition
Tbx1tm2.1Bem/Tbx1tm2.1Bem
Tg(Wnt1-cre)11Rth/0
Genetic
Background
either: (involves: 129/Sv * C57BL/6 * C57BL/6J * CBA/J * SJL) or (involves: 129/Sv * C57BL/6J * CBA/J * CD-1 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1tm2.1Bem mutation (0 available); any Tbx1 mutation (15 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no abnormalities




Genotype
MGI:3035941
cn8
Allelic
Composition
Lmo4tm1Sho/Lmo4tm1Sho
Tg(Wnt1-cre)11Rth/0
Genetic
Background
either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo4tm1Sho mutation (0 available); any Lmo4 mutation (4 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• presphenoid bone formed properly




Genotype
MGI:4413446
cn9
Allelic
Composition
Mrgprdtm1Mjz/?
Rettm1Ddg/Rettm1Ddg
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrgprdtm1Mjz mutation (2 available); any Mrgprd mutation (8 available)
Rettm1Ddg mutation (0 available); any Ret mutation (22 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P14, GFP+ skin neuron projections are reduced and punctate unlike in control Mrgprdtm1Mjz Rettm1Ddg homozygotes
• however, central axonal projections in the thoracic spinal cord exhibit normal lamina specific innervation of peptidergic and nonpectidergic projections




Genotype
MGI:3779094
cn10
Allelic
Composition
Mfn2tm1Dcc/Mfn2tm3Dcc
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2tm1Dcc mutation (0 available); any Mfn2 mutation (17 available)
Mfn2tm3Dcc mutation (2 available); any Mfn2 mutation (17 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutant pups are born at appropriate Mendelian ratio
• after birth, about one third of mutant mice die on postnatal day 1
• all remaining mutant mice die by P17

behavior/neurological
• mice surviving beyond P1 cannot easily regain posture when placed on their backs
• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body
• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

nervous system
• severe defect in postnatal cerebellar growth




Genotype
MGI:5285375
cn11
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm2.1Weg/Sox11tm2.1Weg
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Sox11tm2.1Weg mutation (0 available); any Sox11 mutation (6 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (10 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• massive cell death in the branchial arches without a decrease in cell proliferation




Genotype
MGI:4413445
cn12
Allelic
Composition
Rettm1Ddg/Rettm1Ddg
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Ddg mutation (0 available); any Ret mutation (22 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few mice survive beyond 3 weeks

digestive/alimentary system
• at P14
• enlarged at P14

nervous system
• at P14, non-peptidergic neurons are hypotrophic unlike in control Rettm1Ddg homozygotes
• in the small intestine and colon
• at P14, the dorsal root ganglia is 30% smaller than in control Rettm1Ddg homozygotes

behavior/neurological
• beginning at P3 mice develop progressive weakness

growth/size/body




Genotype
MGI:3851919
cn13
Allelic
Composition
Hdac2tm1.1Eno/Hdac2tm1.1Eno
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2tm1.1Eno mutation (0 available); any Hdac2 mutation (20 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype is detected in skull development




Genotype
MGI:3851918
cn14
Allelic
Composition
Hdac1tm1.1Eno/Hdac1tm1.1Eno
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Eno mutation (0 available); any Hdac1 mutation (21 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype is detected in skull development




Genotype
MGI:3851920
cn15
Allelic
Composition
Hdac8tm1.1Eno/Y
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die within 4-6 hours after birth from brain hemorrhaging

cardiovascular system
• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull

craniofacial
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone

nervous system
• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull

skeleton
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone and incomplete skull closure




Genotype
MGI:5308955
cn16
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• disruption of apical neural tube morphology leading to migration of cells into the neural canal
• malformed telencephalic lobes at E12.5

craniofacial

embryo
• disruption of apical neural tube morphology leading to migration of cells into the neural canal

cellular




Genotype
MGI:5308958
cn17
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at E12.5
• at E12.5
• rudimentary at E12.5

nervous system
• absence of midbrain structures at E10.5
• absence of hindbrain structures at E10.5

embryo
• rudimentary at E12.5

skeleton
• at E12.5
• at E12.5




Genotype
MGI:5308956
cn18
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Ctnnb1tm3Kba mutation (0 available); any Ctnnb1 mutation (27 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• not developed at E10.5

craniofacial
• hypoplastic and malformed

skeleton
• hypoplastic and malformed




Genotype
MGI:5308953
cn19
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Ctnnb1tm3Kba mutation (0 available); any Ctnnb1 mutation (27 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• differentiation of sensory neurons in the neural tube is defective
• milder defects than in conditional mutant mice homozygous for Ctnnb1tm2Kem at E12.5

craniofacial
• milder defects than in conditional mutant mice homozygous for Ctnnb1tm2Kem at E12.5

embryo
N
• apical neural tube morphology is not disrupted at E12.5

cellular
• differentiation of sensory neurons in the neural tube is defective




Genotype
MGI:4868201
cn20
Allelic
Composition
Dicer1tm1Bdh/Dicer1+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (2 available); any Dicer1 mutation (52 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type

immune system
• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type

endocrine/exocrine glands
• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type




Genotype
MGI:4868120
cn21
Allelic
Composition
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (2 available); any Dicer1 mutation (52 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• discontinuance of the ascending aortic arch with the descending aorta, indicating improper pattering of the aortic arch due to a left fourth aortic arch defect
• the outflow tract does not fully septate into a pulmonary artery and aorta in some cases, resulting in the persistence of a common outflow vessel

craniofacial
• severe craniofacial defects are seen by E14.5
• although pharyngeal arches appear similar to wild-type in emergence, size and shape, expression of Dlx2 and Fgf8 are downregulated in pharyngeal arch 1
• apoptosis is increased in the first pharyngeal arch at E11.5

embryo
• although pharyngeal arches appear similar to wild-type in emergence, size and shape, expression of Dlx2 and Fgf8 are downregulated in pharyngeal arch 1
• apoptosis is increased in the first pharyngeal arch at E11.5

hematopoietic system
• thymus development is absent

immune system
• thymus development is absent

nervous system
• loss of neural crest cell derived neuronal tissue from the thoracic sympathetic ganglia
• loss of neural crest cell derived neuronal tissue from the dorsal root ganglia

skeleton
• neural crest cell derived maxillary and mandibular regions of the face and frontonasal process lack cartilaginous tissue, however mesodermally derived cartilage near the base of the skull is present

endocrine/exocrine glands
• thymus development is absent

Mouse Models of Human Disease
OMIM ID Ref(s)
DiGeorge Syndrome; DGS 188400 J:166758




Genotype
MGI:3804086
cn22
Allelic
Composition
Cited2tm1Bha/Cited2tm2Bha
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (4 available); any Cited2 mutation (15 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (15 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning

nervous system
• in one mouse
• 11 of 14 mice exhibit fusion of ganglia IX and X
• 11 of 14 mice exhibit fusion of ganglia IX and X




Genotype
MGI:5430387
cn23
Allelic
Composition
Hs2st1tm1.1Je/Hs2st1tm1.1Je
Hs6st1tm1Wvc/Hs6st1tm1Wvc
Hs6st2tm1Lex/Hs6st2tm1Lex
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hs2st1tm1.1Je mutation (0 available); any Hs2st1 mutation (17 available)
Hs6st1tm1Wvc mutation (0 available); any Hs6st1 mutation (12 available)
Hs6st2tm1Lex mutation (2 available); any Hs6st2 mutation (6 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• lacrimal gland budding is preserved




Genotype
MGI:5702481
cn24
Allelic
Composition
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm3Spe
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2Arbr mutation (1 available); any Mapt mutation (404 available)
Runx1tm3Spe mutation (0 available); any Runx1 mutation (18 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction of sensory innervtion of the epidermic at P0
• reduction in epidermal nerve fiber density




Genotype
MGI:5702479
cn25
Allelic
Composition
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm2.1Ddg mutation (1 available); any Cbfb mutation (29 available)
Mapttm2Arbr mutation (1 available); any Mapt mutation (404 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction of sensory innervation of the epidermis at P0
• reduction in epidermal nerve fiber density
• deficiency of peripheral projections of nonpeptidergic (mechanical) nociceptors

craniofacial

mortality/aging
• mice die perinatally due to craniofacial defects




Genotype
MGI:5305927
cn26
Allelic
Composition
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (24 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (5 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial

nervous system
N
• cranial neural crest cell migration and olfactory placodes are normal

digestive/alimentary system

growth/size/body




Genotype
MGI:5524256
cn27
Allelic
Composition
Nrg1tm4Cbm/Nrg1tm4.1Cbm
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (17 available)
Nrg1tm4Cbm mutation (0 available); any Nrg1 mutation (17 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal myelination
• small diameter and few intrafusal fibers

behavior/neurological
• on an inverted grid, mice loss their grip 5 times faster than control mice
• impaired left/right coordination with frequent hopping

muscle
• small diameter and few intrafusal fibers




Genotype
MGI:4365544
cn28
Allelic
Composition
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1.1Wbm mutation (1 available); any Ptpn11 mutation (25 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit reduced axonal arborization compared to in wild-type mice
• however, incubation with wild-type Schwann cells restores axon outgrowth
• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation unlike in wild-type mice
• Ret+ enteric neural crest cells are reduced compared to in wild-type mice
• at E11.5, BFABP+ Schwann cell precursors are reduced compared to in wild-type mice
• at E12.5, Sox10+ Schwann cell precursors are not detected in peripheral nerves unlike in wild-type mice
• at E13.5, Schwann cell nuclei in peripheral nerves are virtually absent unlike in wild-type mice
• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation and reduced axonal arborization compared to in wild-type mice
• at E12.5, lumbar dorsal root ganglia sensory neurons exhibit increased cell death compared to in wild-type mice
• numbers of sensory neurons in the dorsal root ganglia are strongly reduced compared to in wild-type mice

craniofacial

pigmentation
• melanocytes are reduced in number compared to in wild-type mice

embryo
• Ret+ enteric neural crest cells are reduced compared to in wild-type mice

cellular
• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit reduced axonal arborization compared to in wild-type mice
• however, incubation with wild-type Schwann cells restores axon outgrowth
• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation unlike in wild-type mice




Genotype
MGI:3653215
cn29
Allelic
Composition
Gja1tm1Kwi/Gja1tm1Kwi
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1Kwi mutation (1 available); any Gja1 mutation (39 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• normal embryonic development and cardiac morphogenesis is observed




Genotype
MGI:3811608
cn30
Allelic
Composition
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm3Jzh mutation (0 available); any Pkd1 mutation (68 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• the sphenoid bones are much smaller
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the presphenoid bone
• the growth of the upper jaw is profoundly retarded where the nasal, premaxillary and maxillary bones are severely reduced in length by three weeks of age
• mineralization of the caudal nasal bone is markedly reduced
• noticeable by three weeks after birth
• maxilla hypoplasia leads to an abnormal apposition of the incisors (class III malocclusion)
• shortened and bent snouts are obvious three weeks after birth resulting from abnormal nasal bone growth in the rostral direction

skeleton
• the sphenoid bones are much smaller
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the presphenoid bone
• the growth of the upper jaw is profoundly retarded where the nasal, premaxillary and maxillary bones are severely reduced in length by three weeks of age
• mineralization of the caudal nasal bone is markedly reduced
• noticeable by three weeks after birth
• maxilla hypoplasia leads to an abnormal apposition of the incisors (class III malocclusion)
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the sphenoid bones
• there is a population of apoptotic cells in the perichondrium of the presphenoid synchondrosis prior to its closure
• synchondrosal chondrocytes have reduced proliferative activity
• there is a population of apoptotic cells in the perichondrium of the presphenoid synchondrosis prior to its closure
• there is a delay in the intramembranous ossification of the facial and calvarial bones noted at 5 days after birth

growth/size/body
• shortened and bent snouts are obvious three weeks after birth resulting from abnormal nasal bone growth in the rostral direction




Genotype
MGI:5659950
cn31
Allelic
Composition
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Wds mutation (0 available); any Braf mutation (30 available)
Raf1tm2Bacc mutation (0 available); any Raf1 mutation (95 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• in 4 of 6 mice at E17.5
• mild conotruncal defects at E16.5
• in 4 of 6 mice at E17.5 with 1 mouse also exhibiting double outlet right ventricle

endocrine/exocrine glands
• in 5 of 8 mice at E16.5 and E17.5
• hypoplastic or malpositioned in 2 of 3 mice at E16.5
• hypoplastic or malpositioned in 2 of 3 mice at E16.5

craniofacial

growth/size/body
N
• mice exhibit normal embryonic crown-rump length

hearing/vestibular/ear
N
• mice exhibit normal external ear

skeleton

immune system
• in 5 of 8 mice at E16.5 and E17.5

hematopoietic system
• in 5 of 8 mice at E16.5 and E17.5

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiofaciocutaneous Syndrome 1; CFC1 115150 J:144862




Genotype
MGI:3697616
cn32
Allelic
Composition
Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mkl2Gt(RRJ478)Byg mutation (1 available); any Mkl2 mutation (50 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected numbers of newborns are seen (11.5% instead of the expected 25%), indicating partial lethality, however lethality is lower than in single Mkl2 homozygotes




Genotype
MGI:5707466
cn33
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (250 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no embryonic or perinatal lethality




Genotype
MGI:4438212
cn34
Allelic
Composition
Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• numerous anomalies are evident in the branching pattern of the facial nerve




Genotype
MGI:5298219
cn35
Allelic
Composition
Pitx2tm1.1Sac/Pitx2tm2Sac
Tg(Wnt1-cre)11Rth/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Pitx2tm1.1Sac mutation (1 available); any Pitx2 mutation (15 available)
Pitx2tm2Sac mutation (0 available); any Pitx2 mutation (15 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• devoid of pigment except for a cone shaped region in the anterior segment
• retinal pigment layer is normal at E10.5 but pigment loss begins at E12.5
• corneal stroma and epithelium are absent
• hypomorphic hyaloid blood vessels
• muscle bundles present adjacent to the anterior segment
• eye stalk fails to extend at E12.5
• eyes directly attached to ventral diencephalon by E14.5
• retinal ganglion cell axons enter ventral thalamus and form an optic chiasma-like structure
• eyes are not visible externally at E16.5
• eyes present but buried within the skull near the midline directly beneath the brain
• lens and retina present

pigmentation
• devoid of pigment except for a cone shaped region in the anterior segment
• retinal pigment layer is normal at E10.5 but pigment loss begins at E12.5

nervous system

muscle
• muscle bundles present adjacent to the anterior segment




Genotype
MGI:5447985
cn36
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
HhatTg(TFAP2A-cre)1Will mutation (1 available); any Hhat mutation (13 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hypoplastic, particularly the trigeminal ganglion
• maxillary branch is consistently narrower than in controls




Genotype
MGI:3639491
cn37
Allelic
Composition
Fgf15tm1Sms/Fgf15tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf15tm1Sms mutation (1 available); any Fgf15 mutation (7 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced
• at E9.5, cardiac NCCs migrate to the developing caudal pharyngeal arches of mutant embryos in numbers comparable to those of wild-type embryos; however, at E11.5, NCCs fail to invaginate on the right side of the proximal aortic sac at the level of its connection with the 6th aortic arch arteries
• as a result, the conotruncal cushions remain oriented laterally relative to one another

cardiovascular system
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced
• homozygotes exhibit abnormal NCC behavior during outflow tract remodeling

nervous system
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced

cellular
• at E9.5, cardiac NCCs migrate to the developing caudal pharyngeal arches of mutant embryos in numbers comparable to those of wild-type embryos; however, at E11.5, NCCs fail to invaginate on the right side of the proximal aortic sac at the level of its connection with the 6th aortic arch arteries
• as a result, the conotruncal cushions remain oriented laterally relative to one another




Genotype
MGI:5440182
cn38
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (27 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within hours of birth probably because of an inability to feed




Genotype
MGI:5440183
cn39
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (27 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• brain defects

craniofacial
• impaired morphogenesis of craniofacial structures




Genotype
MGI:3715254
cn40
Allelic
Composition
Hand2tm1Cse/Hand2tm1Cse
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation (0 available); any Hand2 mutation (2 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• palate is normal
• no changes in cell proliferation or apoptosis are observed in palatal shelves at E13.5




Genotype
MGI:3848967
cn41
Allelic
Composition
Hand2tm1Cse/Hand2tm1Dsr
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation (0 available); any Hand2 mutation (2 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (2 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos begin to die by 12 dpc and no live embryos are recovered at 13 dpc

cardiovascular system
• blood pools in major vessels, heart, liver, and coelom by 12 dpc
• circulatory defects develop by 12 dpc

homeostasis/metabolism
• number of neuronal cells in sympathetic nervous system expressing tyrosine hydroxylase or dopamine beta-hydroxylase is greatly reduced compared to controls at 12.5 dpc

nervous system
N
• neural crest cell colonization of the sympathetic nervous system is normal, and sympathetic nervous system differentiation is unaffected in mutant embryos
• catecholaminergic differentiation of the sympathetic nervous system is abnormal in mutants; fewer neurons produce enzymes needed for synthesis of noradrenaline than in wild-type controls




Genotype
MGI:3710237
cn42
Allelic
Composition
Nf1tm1Par/Nf1tm1Par
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation (4 available); any Nf1 mutation (85 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

respiratory system
• pups do not initiate normal respiration

nervous system
• increase in the number of adrenal medullary cells, suggesting pheochromocytoma
• massively enlarged sympathetic ganglia that consist of axons that stain for neurofilament and small cell bodies with large nuclei that express tyrosine hydroxylase, a morphology consistent with ganglioneuroma or ganglioneurosarcoma

endocrine/exocrine glands
• a thinning and distortion of the adrenal cortex
• increase in the number of adrenal medullary cells, suggesting pheochromocytoma

neoplasm
• develop tumors of neural crest origin such as ganglioneuroma, ganglioneurosarcoma, and pheochromocytoma

cardiovascular system
N
• normal cardiac development

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:80323




Genotype
MGI:3711498
cn43
Allelic
Composition
Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (10 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (10 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at E12.5, lens size is reduced comparable to Pygo2tm1Lan/Pygo2tm1.1Lan mice




Genotype
MGI:3702775
cn44
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (1 available); any Fgfr1 mutation (195 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• dorsal cerebellum development is abnormal
• inferior colliculus is deleted in the posterior midbrain
• the vermis is present but severely malformed




Genotype
MGI:3623411
cn45
Allelic
Composition
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (17 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
• malformations of cranial bones at E18

cardiovascular system
• abnormal branching of the left carotid artery from the brachiocephalic trunk in mutant mice
• venous congestion
• defective separation of the aorta from the pulmonary trunk, leading to persistent truncus arteriosis
• exhibit vasodilatation of the jugular veins
• heart defects lead to functional right-sided heart failure with venous congestion, resulting in a vasodilatation of the jugular veins

endocrine/exocrine glands
• 2 of 5 do not have parathyroid glands
• 3 of 5 exhibit hypoplastic parathyroid glands at E18
• thymus gland is 58% the size of wild-type at E18

immune system
• thymus gland is 58% the size of wild-type at E18

nervous system
• defect in neural crest cell differentiation in the pharyngeal apparatus but not in the migration or survival of neural crest cells
• absence of neural crest-derived smooth muscle cells
• midbrain abnormalities
• hindbrain abnormalities

skeleton
• malformations of cranial bones at E18
• malformation of cartilage at E18

hematopoietic system
• thymus gland is 58% the size of wild-type at E18

digestive/alimentary system

embryo
• defect in neural crest cell differentiation in the pharyngeal apparatus but not in the migration or survival of neural crest cells
• absence of neural crest-derived smooth muscle cells

muscle
• exhibit vasodilatation of the jugular veins

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
DiGeorge Syndrome; DGS 188400 J:96359




Genotype
MGI:3623951
cn46
Allelic
Composition
Gata6tm2Msp/Gata6tm2Msp
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2Msp mutation (0 available); any Gata6 mutation (9 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between E18.5 and P1

cardiovascular system
• exhibit a spectrum of aortic arch patterning and cardiac outflow tract septation defects indistinguishable from those seen in mice homozygous for Gata6tm2Msp and hemizygous for Tg(Tagln-cre)1Jjl
• hypoplastic aortic arch
• seen as early as E9.5
• membranous ventricular septal defect




Genotype
MGI:3817490
cn47
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm2Sev/Isl1tm2Sev
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (336 available)
Isl1tm2Sev mutation (1 available); any Isl1 mutation (16 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within a few hours of birth

nervous system
• cutaneous branch of the ventral ramus is absent in E14.5 embryos
• innervation of the distal limbs at E14.5 confirmed a nearly complete loss of fine cutaneous sensory fibers with only a single sensory branch innervating one side of digits 1, 2 and 5 in both the forelimb and hindlimb
• there is an increased rate of apoptosis within the trigeminal ganglia of E11.5 and E12.5 embryos
• the dorsal root ganglion (DRG) of E12.5 embryos do not express Isl1 protein
• TrkA+ neurons are lower in number starting at E12.5 and by E14.5 are less than one-third of what is found in controls
• TrkB+ neurons are also lower in number starting at E12.5 and are markedly reduced at E14.5 and birth
• TrkC+ neurons do not appear until E12.5, a delay of two days compared to controls
• the DRG of E14.5 embryos is markedly smaller than controls with a smaller number neurons found within the ganglion
• an increased rate of apoptosis is noted in the E12.5 DRG

behavior/neurological
• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs

integument
• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs




Genotype
MGI:3697607
cn48
Allelic
Composition
Acvr1tm1Vk/Acvr1tm1.1Vk
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1.1Vk mutation (0 available); any Acvr1 mutation (22 available)
Acvr1tm1Vk mutation (0 available); any Acvr1 mutation (22 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants that are born alive die during the first postnatal day
• about 40% die in utero (J:90453)
• only 60% of expected numbers are recovered at birth, however the expected numbers are recovered at E14, indicating 40% lethality between E14 and birth (J:90988)

cardiovascular system
• display abnormal regression of the pharyngeal arch arteries
• at E11.5, the 6th arteries display bilaterally inappropriate regression
• at E11.5, the 3rd arteries display bilaterally inappropriate regression
• aortic arch defects
• 77% exhibit either a short or missing brachiocephalic artery so that the right common carotid artery directly branches from the truncus arteriosus
• 77% exhibit either a short or missing brachiocephalic artery
• the distal outflow tract has reduced numbers of neural crest cells
• the proximal outflow tract is essentially devoid of neural crest cells
• differentiation of neural crest cells to smooth muscle around aortic arch arteries is deficient
• the proximal outflow tract is essentially devoid of neural crest cells while the distal outflow tract has reduced numbers of neural crest cells
• outflow tract cushions are reduced in size
• 100% penentrance or persistent truncus arteriosus type A2 (complete failure of outflow tract septation)
• persistent truncus arteriosus is associated with a ventricular septation defect
• 100% penetrance
• 85% show hyperplastic right ventricle

nervous system
• the distal outflow tract has reduced numbers of neural crest cells
• the proximal outflow tract is essentially devoid of neural crest cells
• differentiation of neural crest cells to smooth muscle around aortic arch arteries is deficient

craniofacial
• display abnormal regression of the pharyngeal arch arteries
• at E11.5, the 6th arteries display bilaterally inappropriate regression
• at E11.5, the 3rd arteries display bilaterally inappropriate regression
• squamous parts of the frontal bones lack ossification towards the metopic region, resulting in enlarged frontal fontanels in newborns
• squamal bones lack the retrotympanic process
• the temporal squama is smaller, lacking the lower portion with the mandibular fossa and its joint cartilage
• zygomatic arches are incomplete in newborns, with developed maxillary zygomatic process but completely absent jugal (zygomatic) bone and zygomatic process of the squamal bone
• coronoid process of the mandible is rudimentary in size
• the mental symphysis is not formed resulting in persistently separate mandibular bones
• hypotrophic mandible is apparent as early as E14
• mandible is about 40% shorter
• completely absent jugal (zygomatic) bone
• slightly shorter manubrium mallei
• the anterior cartilage derived from the distal extremity of Meckel's cartilage is absent
• anterior region of Meckel's cartilage displays retarded growth and also fails to fuse at E15
• display approximately a 3-fold reduction in proliferation of chondrocytes in the anterior and interior parts of Meckel's cartilage at E13
• complete cleft of the secondary palate
• palatal shelves fail to elevate, either bilaterally or unilaterally, at E14
• in newborns, the unfused palatal shelves are bilaterally elevated, indicating that cleft palate develops as a result of delayed, asynchronous elevation of palatal shelves
• newborns have a shorter head

embryo
• display abnormal regression of the pharyngeal arch arteries
• at E11.5, the 6th arteries display bilaterally inappropriate regression
• at E11.5, the 3rd arteries display bilaterally inappropriate regression
• the distal outflow tract has reduced numbers of neural crest cells
• the proximal outflow tract is essentially devoid of neural crest cells
• differentiation of neural crest cells to smooth muscle around aortic arch arteries is deficient
• migration of mutant neural crest cells to the outflow tract is impaired

behavior/neurological
• newborns lack milk in stomachs and fail to suckle

digestive/alimentary system
• complete cleft of the secondary palate
• palatal shelves fail to elevate, either bilaterally or unilaterally, at E14
• in newborns, the unfused palatal shelves are bilaterally elevated, indicating that cleft palate develops as a result of delayed, asynchronous elevation of palatal shelves

hearing/vestibular/ear
• slightly shorter manubrium mallei

skeleton
• squamous parts of the frontal bones lack ossification towards the metopic region, resulting in enlarged frontal fontanels in newborns
• squamal bones lack the retrotympanic process
• the temporal squama is smaller, lacking the lower portion with the mandibular fossa and its joint cartilage
• zygomatic arches are incomplete in newborns, with developed maxillary zygomatic process but completely absent jugal (zygomatic) bone and zygomatic process of the squamal bone
• coronoid process of the mandible is rudimentary in size
• the mental symphysis is not formed resulting in persistently separate mandibular bones
• hypotrophic mandible is apparent as early as E14
• mandible is about 40% shorter
• completely absent jugal (zygomatic) bone
• slightly shorter manubrium mallei
• secondary cartilage of the mandibular condyle does not develop, making the temporomandibular articulation undetectable
• the secondary cartilage of the mandibular angular process is completely missing
• the anterior cartilage derived from the distal extremity of Meckel's cartilage is absent
• anterior region of Meckel's cartilage displays retarded growth and also fails to fuse at E15
• display approximately a 3-fold reduction in proliferation of chondrocytes in the anterior and interior parts of Meckel's cartilage at E13

cellular
• differentiation of neural crest cells to smooth muscle around aortic arch arteries is deficient
• migration of mutant neural crest cells to the outflow tract is impaired

growth/size/body
• complete cleft of the secondary palate
• palatal shelves fail to elevate, either bilaterally or unilaterally, at E14
• in newborns, the unfused palatal shelves are bilaterally elevated, indicating that cleft palate develops as a result of delayed, asynchronous elevation of palatal shelves
• newborns have a shorter head




Genotype
MGI:3804318
cn49
Allelic
Composition
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Pax3)Joe mutation (0 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sortm2Joe/Gt(ROSA)26Sortm2Joe Pax3tm1(cre)Joe/Pax3+ mice
• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sortm2Joe/Gt(ROSA)26Sortm2Joe Pax3tm1(cre)Joe/Pax3+ mice

vision/eye
• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sortm2Joe/Gt(ROSA)26Sortm2Joe Pax3tm1(cre)Joe/Pax3+ mice

digestive/alimentary system
• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sortm2Joe/Gt(ROSA)26Sortm2Joe Pax3tm1(cre)Joe/Pax3+ mice

growth/size/body
• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sortm2Joe/Gt(ROSA)26Sortm2Joe Pax3tm1(cre)Joe/Pax3+ mice




Genotype
MGI:3804321
cn50
Allelic
Composition
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Pax3)Joe mutation (0 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• in one mouse

digestive/alimentary system
• in one mouse

growth/size/body
• in one mouse




Genotype
MGI:3711516
cn51
Allelic
Composition
Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Pax6-cre,GFP)1Pgr/?
Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (10 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (10 available)
Tg(Pax6-cre,GFP)1Pgr mutation (1 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at E12.5, lens reduction is more severe that in either single cre cross but not as severe as in the Pygo2 null homozygotes




Genotype
MGI:3703442
cn52
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (1 available); any Fgfr1 mutation (195 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• at E9.5, no defects are seen in the early development of the second branchial arch unlike mice homozygous for Fgfr1tm2Jrt
• also, the malleus, incus, stapes, styloid process, tympanic ring, alisphenoid and squamosum are normal
• lesser horn points laterally
• in newborns

digestive/alimentary system
• in newborns

skeleton
• lesser horn points laterally

growth/size/body
• in newborns




Genotype
MGI:3703441
cn53
Allelic
Composition
Fgfr1tm2Jrt/Fgfr1tm2Jrt
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm2Jrt mutation (1 available); any Fgfr1 mutation (195 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• the palate is closed, unlike in mice homozygous for Fgfr1tm2Jrt alone
• posterior part are always affected
• posterior part are always affected
• reduced gonial bone
• variable deficiencies
• variable deficiencies
• disruption in second branchial arch development is similar to that in Fgfr1tm2Jrt homozygotes

hearing/vestibular/ear
• reduced gonial bone
• variable deficiencies
• variable deficiencies

skeleton
• posterior part are always affected
• posterior part are always affected
• reduced gonial bone
• variable deficiencies
• variable deficiencies

embryo
• disruption in second branchial arch development is similar to that in Fgfr1tm2Jrt homozygotes




Genotype
MGI:3703447
cn54
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (195 available)
Fgfr1tm1Jpa mutation (1 available); any Fgfr1 mutation (195 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• at E9.5, no defects are seen in the early development of the second branchial arch unlike mice homozygous for Fgfr1tm2Jrt
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

digestive/alimentary system

skeleton
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

growth/size/body




Genotype
MGI:3814191
cn55
Allelic
Composition
Ednrbtm1Nrd/Ednrbtm1Nrd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1Nrd mutation (1 available); any Ednrb mutation (73 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die 5 weeks after birth

growth/size/body

digestive/alimentary system

pigmentation
• mice lack coat pigment in the trunk

embryo
• enteric neural crest cells fail to reach the anus

integument
• mice lack coat pigment in the trunk

cellular
• enteric neural crest cells fail to reach the anus




Genotype
MGI:5660196
cn56
Allelic
Composition
Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Gela mutation (1 available); any Mapk1 mutation (24 available)
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (11 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• more severe than in mice with normal Mapk3

craniofacial
• more severe than in mice with normal Mapk3
• more severe than in mice with normal Mapk3
• more severe than in mice with normal Mapk3

cardiovascular system
• in 3 of 3 mice at E16.5 and E17.5
• in 3 of 3 mice at E16.5 and E17.5

endocrine/exocrine glands
• single-lobed, fused and misplaced
• singled-lobed and medially localized

digestive/alimentary system
• more severe than in mice with normal Mapk3

hematopoietic system
• single-lobed, fused and misplaced

immune system
• single-lobed, fused and misplaced

skeleton
• more severe than in mice with normal Mapk3
• more severe than in mice with normal Mapk3

vision/eye




Genotype
MGI:4443124
cn57
Allelic
Composition
Kif3atm2Gsn/Kif3atm2Gsn
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif3atm2Gsn mutation (1 available); any Kif3a mutation (15 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• increased neural crest cell proliferation in the facial prominences, as shown by BrdU immunostaining
• cranial neural crest cells do not extend primary cilia
• primary cilia are truncated in frontonasal prominence

nervous system
• cranial neural crest cells do not extend primary cilia
• primary cilia are truncated in frontonasal prominence
• failure of neural fibers to span the midline

craniofacial
• craniofacial skeleton elements are displaced laterally but their maturation is unaffected
• severely dysmorphic
• anterior cranium occultum
• trabecular basal plate is reduced to bony nodules or absent at E17.5
• is reduced to bony nodules or absent at E17.5
• laterally displaced and underdeveloped resulting in an abnormal opening in the skull
• 30% shorter than wild-type
• laterally displaced at E17.5
• laterally displaced at E17.5
• laterally displaced at E17.5
• the palatine bones are dysmorphic and do not extend towards the midline
• some small ectopic ossifications are found in the midline which may or may not be fragments of the palatine bones
• at E11.5 and E12.5 infra-nasal measurements show an increase in frontonasal width
• at E14.5, almost 100% wider than wild-type and at E17.5 120% wider than wild-type
• at E12.5, septum is evident as a bifid condensation and by E16.5 a duplicated nasal septum is present

digestive/alimentary system

skeleton
• craniofacial skeleton elements are displaced laterally but their maturation is unaffected
• severely dysmorphic
• anterior cranium occultum
• trabecular basal plate is reduced to bony nodules or absent at E17.5
• is reduced to bony nodules or absent at E17.5
• laterally displaced and underdeveloped resulting in an abnormal opening in the skull
• 30% shorter than wild-type
• laterally displaced at E17.5
• laterally displaced at E17.5
• laterally displaced at E17.5
• the palatine bones are dysmorphic and do not extend towards the midline
• some small ectopic ossifications are found in the midline which may or may not be fragments of the palatine bones

respiratory system
• at E12.5, septum is evident as a bifid condensation and by E16.5 a duplicated nasal septum is present

vision/eye

cellular
• increased neural crest cell proliferation in the facial prominences, as shown by BrdU immunostaining

growth/size/body
• at E12.5, septum is evident as a bifid condensation and by E16.5 a duplicated nasal septum is present




Genotype
MGI:5659973
cn58
Allelic
Composition
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm1.1Cmch mutation (0 available); any Dph1 mutation (16 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 11.1% mice are viable at weaning, indicating partial lethality

craniofacial
• skull length is shorter at P0 with an approximate 5% reduction
• skull of surviving adult mice is shorter in length