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Targeted Allele Detail
Symbol: Nf1tm1Tyj
Name: neurofibromin 1; targeted mutation 1, Tyler Jacks
MGI ID: MGI:1857478
Synonyms: Nf1-, Nf1n31
Gene: Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance: Nf1tm1Tyj page
Germline Transmission:  Earliest citation of germline transmission: J:18542
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the first 42 codons of exon 31, the exon 31 splice acceptor site, and approximately 2 kb of intron 30. This allele is a null allele; no stable full-length protein is made. (J:18542)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Nf1tm1Tyj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  111 strains or lines available
Original:  J:18542 Jacks T, et al., Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet. 1994 Jul;7(3):353-61
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory