cleft palate Disease Ontology Browser

Disease Ontology Browser

cleft palate (DOID:674)
Alliance: disease page
Synonyms: Palatoschisis
Alt IDs: ICD10CM:Q35, ICD9CM:749.0, ICD9CM:749.00, MESH:D002972, NCI:C87069, ORDO:99772, UMLS_CUI:C0008925
Definition: An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.

Term Browser
Genes (22)
Models (17)

Disease References using Mouse Models (10)

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Transgene: Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis/0 Tg(KRT14-cre)1Amc/0	involves: C57BL/6 * CBA * DBA/2	J:233662	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: b2b1470Clo

Allelic Composition	Genetic Background	Reference	Phenotypes
b2b1470Clo/b2b1470Clo	C57BL/6J-b2b1470Clo	J:175213	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: b2b1594Clo

Allelic Composition	Genetic Background	Reference	Phenotypes
b2b1594Clo/b2b1594Clo	C57BL/6J-b2b1594Clo	J:175213	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: Cdc42

Allelic Composition	Genetic Background	Reference	Phenotypes
Cdc42tm1.1Ayam/Cdc42tm1.1Ayam Tg(Mpz-cre)94Imeg/0	Not Specified	J:250065	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: Golgb1

Allelic Composition	Genetic Background	Reference	Phenotypes
Golgb1m1Lanyu/Golgb1m1Lanyu	A/J-Golgb1^m1Lanyu	J:235669	View
Golgb1em8Lanyu/Golgb1em8Lanyu	FVB/NJ-Golgb1^em8Lanyu	J:235669	View
Golgb1em33Lanyu/Golgb1em33Lanyu	FVB/NJ-Golgb1^em8Lanyu	J:235669	View
Golgb1em8Lanyu/Golgb1em33Lanyu	FVB/NJ-Golgb1^em8Lanyu	J:235669	View
Golgb1em33Lanyu/Golgb1m1Lanyu	involves: A/J * FVB/NJ	J:235669	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: Prmt1

Allelic Composition	Genetic Background	Reference	Phenotypes
Prmt1tm1Rchd/Prmt1tm1Rchd H2az2Tg(Wnt1-cre)11Rth/H2az2+	involves: 129/Sv * C57BL/6J * CBA/J	J:289243	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: Six2

Allelic Composition	Genetic Background	Reference	Phenotypes
Six2tm3(EGFP/cre/ERT2)Amc/Six2tm3(EGFP/cre/ERT2)Amc	involves: 129/Sv * C57BL/6J	J:285711	View

Mouse Models

Human Disease Modeled: cleft palate
Associated Mouse Gene: Specc1l

Allelic Composition	Genetic Background	Reference	Phenotypes
Specc1lem4Kumc/Specc1l+	involves: C57BL/6J * FVB/NJ	J:324294	View
Specc1lem3Kumc/Specc1l+	involves: C57BL/6J * FVB/NJ	J:324294	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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