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Cdc42 Gene Detail
Summary
  • Symbol
    Cdc42
  • Name
    cell division cycle 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:106211
    NCBI Gene: 12540
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137047007-137085031 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.83 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106211
 protein coding gene Chr4:137047007-137085070 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028979
 protein coding gene Chr4:139933645-139972589 (-)
A/J MGP_AJ_G0028938
 protein coding gene Chr4:133986368-134025106 (-)
AKR/J MGP_AKRJ_G0028890
 protein coding gene Chr4:137842675-137880521 (-)
BALB/cJ MGP_BALBcJ_G0028962
 protein coding gene Chr4:134649220-134687319 (-)
C3H/HeJ MGP_C3HHeJ_G0028676
 protein coding gene Chr4:138134614-138175850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029403
 protein coding gene Chr4:144899954-144941504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026674
 protein coding gene Chr4:127007991-127043364 (-)
CAST/EiJ MGP_CASTEiJ_G0028108
 protein coding gene Chr4:136288895-136333405 (-)
CBA/J MGP_CBAJ_G0028641
 protein coding gene Chr4:148941271-148987330 (-)
DBA/2J MGP_DBA2J_G0028790
 protein coding gene Chr4:134382887-134421389 (-)
FVB/NJ MGP_FVBNJ_G0028757
 protein coding gene Chr4:133354808-133393068 (-)
LP/J MGP_LPJ_G0028889
 protein coding gene Chr4:140020769-140059831 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028783
 protein coding gene Chr4:153051353-153093656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029441
 protein coding gene Chr4:138314605-138353651 (-)
PWK/PhJ MGP_PWKPhJ_G0027828
 protein coding gene Chr4:131190004-131230031 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027654
 protein coding gene Chr4:134120989-134162390 (-)
WSB/EiJ MGP_WSBEiJ_G0028186
 protein coding gene Chr4:138485029-138524831 (-)



Homology
more
  • Human Ortholog
    CDC42, cell division cycle 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC42, cell division cycle 42
  • Synonyms
    CDC42Hs, G25K, TKS
  • Links
    NCBI Gene ID: 998
    neXtProt AC: NX_P60953
    UniProt: P60953

  • Chr Location
    1p36.12; chr1:22052627-22092943 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Cdc42 mouse models; 1 with human CDC42 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    145 phenotypes from 8 alleles in 14 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    125 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    155
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1046
  • Tissues
    189
  • cDNA Data
    52
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006699 Ensembl Gene Model | MGI Sequence Detail 38025 C57BL/6J ±  kb
    transcript ENSMUST00000051477 Ensembl | MGI Sequence Detail 2108 Not Applicable  
    polypeptide ENSMUSP00000054634 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 1
      cDNA 52
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33903, MGI:2140354, MGI:2140443
    References
    more
    • Summaries
      All 372
      Developmental Gene Expression 87
      Diseases 2
      Gene Ontology 49
      Phenotypes 125
    • Earliest
      J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
    • Latest
      J:328236 Jiang R, et al., CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport. Cell Death Dis. 2022 Sep 2;13(9):757
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/14/2023
    MGI 6.22     		The Jackson Laboratory