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Cdc42tm1Brak
Targeted Allele Detail
Summary
Symbol: Cdc42tm1Brak
Name: cell division cycle 42; targeted mutation 1, Cord Brakebusch
MGI ID: MGI:3619134
Synonyms: Cdc42fl, Cdc42flox
Gene: Cdc42  Location: Chr4:137047011-137085007 bp, - strand  Genetic Position: Chr4, 69.83 cM
Alliance: Cdc42tm1Brak page
Kidney abnormalities in Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105811
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 2 was flanked with loxP sites via homologous recombination. (J:105811)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 126 assay results
In Structures Affected by this Mutation: 20 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cdc42tm1Brak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:  43 strains or lines available
References
Original:  J:105811 Wu X, et al., Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory