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Phenotype Image Detail
Caption Loss of Cdc42 phenocopies the Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ phenotype. (A,B) Macroscopic view of the urogenital system from wild-type and Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ (Cdc42CM-/-) kidneys at P0. Note the reduction in kidney bladder size in mutant animals. (C-F) PAS staining (P0) from wild-type and mutant animals showing smaller papilla (arrows), dramatic reduction of both CM-derived epithelial structures and glomeruli in the mutant. (G-J) Sections of P0 kidneys using late nephron-specific markers confirms the abnormal glomeruli and proximal tubules formation in mutant kidneys. Glomeruli (Podocin, G,H). Proximal tubules (LTL,I,J). (K,L) NCAM staining (E15.5) reveals dramatic reduction in the number of CM-derived structures (arrowheads) in mutants compared to wild-type. k: kidney; b: bladder; g: glomeruli; pt: proximal tubule. Scale bars represent 1 mm (A-D), 200 um (E-L).
Copyright This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Symbol Name
Cdc42tm1Brak cell division cycle 42; targeted mutation 1, Cord Brakebusch
Six2tm1(tTA,tetO-EGFP/cre)Amc sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Allelic Composition Genetic Background
involves: 129 * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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