Phenotypes Associated with This Genotype

Genotype
MGI:7335182

• Allelic Composition: Cdc42^tm1.1Ayam/Cdc42^tm1.1Ayam; Tg(Mpz-cre)94Imeg/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:250065 )

• nearly all die within 1 day of birth and appear weak with no milk in their stomachs

behavior/neurological

absent gastric milk in neonates ( J:250065 )

craniofacial

abnormal craniofacial bone morphology ( J:250065 )

• severe deformities in the cranial bones

abnormal frontal bone morphology ( J:250065 )

• either reduced ossification or hypoplastic at E16.5 and e18.5

abnormal mandible morphology ( J:250065 )

maxillary shelf hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal premaxilla morphology ( J:250065 )

• unfused nasal capsule

short premaxilla ( J:250065 )

short maxilla ( J:250065 )

abnormal nasal bone morphology ( J:250065 )

palatine bone horizontal plate hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal medial nasal prominence morphology ( J:250065 )

• at E12.5 and E13.5, medial nasal processes fail to merge

abnormal secondary palate development ( J:250065 )

• at E15.5 coalescence of the palatal shelves is not seen

• however, up to E14.5 palatal shelf development appears similar to controls

absent palatal shelf ( J:250065 )

• absence of palatal shelves associated with hypoplastic palatine bone

cleft palate ( J:250065 )

• in all mice

failure of palatal shelf elevation ( J:250065 )

abnormal nasal septum morphology ( J:250065 )

• at E12.5 and E13.5 the nasal septum is divided into right and left in the anterior position

short snout ( J:250065 )

• in 13 of 15 mice

facial cleft ( J:250065 )

• in 13 of 15 mice

cardiovascular system

intracranial hemorrhage ( J:250065 )

• occasionally seen

nervous system

intracranial hemorrhage ( J:250065 )

• occasionally seen

digestive/alimentary system

maxillary shelf hypoplasia ( J:250065 )

• at E16.5 and E18.5

palatine bone horizontal plate hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal secondary palate development ( J:250065 )

• at E15.5 coalescence of the palatal shelves is not seen

• however, up to E14.5 palatal shelf development appears similar to controls

absent palatal shelf ( J:250065 )

• absence of palatal shelves associated with hypoplastic palatine bone

cleft palate ( J:250065 )

• in all mice

failure of palatal shelf elevation ( J:250065 )

growth/size/body

abnormal frontal bone morphology ( J:250065 )

• either reduced ossification or hypoplastic at E16.5 and e18.5

abnormal mandible morphology ( J:250065 )

maxillary shelf hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal premaxilla morphology ( J:250065 )

• unfused nasal capsule

short premaxilla ( J:250065 )

short maxilla ( J:250065 )

abnormal nasal bone morphology ( J:250065 )

palatine bone horizontal plate hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal secondary palate development ( J:250065 )

• at E15.5 coalescence of the palatal shelves is not seen

• however, up to E14.5 palatal shelf development appears similar to controls

absent palatal shelf ( J:250065 )

• absence of palatal shelves associated with hypoplastic palatine bone

cleft palate ( J:250065 )

• in all mice

failure of palatal shelf elevation ( J:250065 )

abnormal nasal septum morphology ( J:250065 )

• at E12.5 and E13.5 the nasal septum is divided into right and left in the anterior position

short snout ( J:250065 )

• in 13 of 15 mice

facial cleft ( J:250065 )

• in 13 of 15 mice

skeleton

abnormal craniofacial bone morphology ( J:250065 )

• severe deformities in the cranial bones

abnormal frontal bone morphology ( J:250065 )

• either reduced ossification or hypoplastic at E16.5 and e18.5

abnormal mandible morphology ( J:250065 )

maxillary shelf hypoplasia ( J:250065 )

• at E16.5 and E18.5

abnormal premaxilla morphology ( J:250065 )

• unfused nasal capsule

short premaxilla ( J:250065 )

short maxilla ( J:250065 )

abnormal nasal bone morphology ( J:250065 )

palatine bone horizontal plate hypoplasia ( J:250065 )

• at E16.5 and E18.5

respiratory system

abnormal nasal bone morphology ( J:250065 )

abnormal nasal septum morphology ( J:250065 )

• at E12.5 and E13.5 the nasal septum is divided into right and left in the anterior position

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cleft palate		DOID:674		J:250065