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Phenotypes Associated with This Genotype
Genotype
MGI:7286374
Allelic
Composition		 Specc1lem4Kumc/Specc1l+
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lem4Kumc mutation (0 available); any Specc1l mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:324294 )
• Background Sensitivity: rarely see females at weaning when backcrossed to C57BL/6 for approximately 6 generations

craniofacial
cleft palate ( J:324294 )
• low level of penetrance

digestive/alimentary system
cleft palate ( J:324294 )
• low level of penetrance

growth/size/body
cleft palate ( J:324294 )
• low level of penetrance
omphalocele ( J:324294 )
• low level of penetrance

vision/eye
coloboma ( J:324294 )
• low level of penetrance

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cleft palate DOID:674 J:324294

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory