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Transgenic Allele Detail
Symbol: H2az2Tg(Wnt1-cre)11Rth
Name: H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
MGI ID: MGI:2386570
Synonyms: Tg(Wnt1-cre)11Rth, Wnt1cre, Wnt1Cre, Wnt1-Cre, Wnt1::Cre
Gene: H2az2  Location: Chr11:6377229-6394443 bp, - strand  Genetic Position: Chr11, 4.01 cM
Alliance: H2az2Tg(Wnt1-cre)11Rth page
Evidence of inflammation in both the proximal and mid-colon of the Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/0 animals

Show the 19 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6J x CBA/J)F1/J
Transgene Type:    Transgenic (Recombinase)
Mutations:    Insertion, Intragenic deletion
H2az2Tg(Wnt1-cre)11Rth expression driven by 1 gene
Mutation detailsThe Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. Line 11 inserted into the gene at 6425500-6456783 (Build GRCm38/mm10) resulting in a 31,283 bp deletion. Founder line x has a copy number of greater than 5. (J:69326)
 Tissue activity of this recombinase allele
Driver: Wnt1 (species not specified)
Summary of all recombinase alleles driven by Wnt1.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying H2az2Tg(Wnt1-cre)11Rth
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any H2az2 Mutation:  26 strains or lines available
Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Original:  J:69326 Danielian PS, et al., Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol. 1998 Dec 3;8(24):1323-6
All:  807 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory