Phenotypes Associated with This Genotype

Genotype
MGI:6470640

• Allelic Composition: Six2^{tm3(EGFP/cre/ERT2)Amc}/Six2^{tm3(EGFP/cre/ERT2)Amc}
• Genetic Background: involves: 129/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:285711 )

• die shortly after birth

craniofacial

domed cranium ( J:285711 )

abnormal palatal mesenchymal cell proliferation ( J:285711 )

• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate

abnormal palatal shelf bone ossification ( J:285711 )

• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate

palatal shelves fail to meet at midline ( J:285711 )

• at E16.5 palatal shelves fail to extend to the midline

cleft palate ( J:285711 )

• in 22% of embryos

delayed palatal shelf elevation ( J:285711 )

• at E14.5

short snout ( J:285711 )

skeleton

domed cranium ( J:285711 )

digestive/alimentary system

abnormal palatal mesenchymal cell proliferation ( J:285711 )

• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate

abnormal palatal shelf bone ossification ( J:285711 )

• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate

palatal shelves fail to meet at midline ( J:285711 )

• at E16.5 palatal shelves fail to extend to the midline

cleft palate ( J:285711 )

• in 22% of embryos

delayed palatal shelf elevation ( J:285711 )

• at E14.5

growth/size/body

abnormal palatal mesenchymal cell proliferation ( J:285711 )

• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate

abnormal palatal shelf bone ossification ( J:285711 )

• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate

palatal shelves fail to meet at midline ( J:285711 )

• at E16.5 palatal shelves fail to extend to the midline

cleft palate ( J:285711 )

• in 22% of embryos

delayed palatal shelf elevation ( J:285711 )

• at E14.5

short snout ( J:285711 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cleft palate		DOID:674		J:285711