Hic2^{Gt(E225A08)1.1Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Hic2^{Gt(E225A08)1.1Wrst}
• Name: hypermethylated in cancer 2; gene trap E225A08, 1.1, German Gene Trap Consortium
• MGI ID: MGI:5703657
• Synonyms: Hic^FL
• Gene: Hic2 Location: Chr16:17051451-17081294 bp, + strand Genetic Position: Chr16, 10.68 cM, cytoband B1
• Alliance: Hic2^{Gt(E225A08)1.1Wrst} page

Mutation origin

• Mutant Cell Line: E225A08
• Germline Transmission: Earliest citation of germline transmission: J:225226
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (No functional change)
• Mutation: Insertion of gene trap vector Vector: rsFROSAbgeo+2s
• Mutation details: Hic2^{Gt(E225A08)Wrst} mice were crossed to a ubiquitously expressed ActB-Flpe transgenic line. This inverts the genetrap, inactivating the splice acceptor, and a wild-type transcript is expressed. (J:225226)

Expression

In Mice Carrying this Mutation:	18 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hic2 Mutation: 257 strains or lines available

References

• Original: J:225226 Dykes IM, et al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
• All: 1 reference(s)