Rhoa^tm1Yuyo
Targeted Allele Detail

Summary

• Symbol: Rhoa^tm1Yuyo
• Name: ras homolog family member A; targeted mutation 1, Yutaka Yoshida
• MGI ID: MGI:5004976
• Synonyms: RhoA^flox
• Gene: Rhoa Location: Chr9:108183359-108215142 bp, + strand Genetic Position: Chr9, 59.2 cM
• Alliance: Rhoa^tm1Yuyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172044
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:172044)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhoa Mutation: 70 strains or lines available

References

• Original: J:172044 Katayama K, et al., Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7607-12
• All: 24 reference(s)