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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhoatm1Yuyo
targeted mutation 1, Yutaka Yoshida
MGI:5004976
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rhoatm1Yuyo/Rhoatm1Yuyo
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd MGI:5004979
cn2
 		Rhoatm1Yuyo/Rhoatm1Yuyo
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:5004977


Genotype
MGI:5004979
cn1
Allelic
Composition		 Rhoatm1Yuyo/Rhoatm1Yuyo
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (31 available)
Rhoatm1Yuyo mutation (0 available); any Rhoa mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:172044 )
• the apical/ventricular surface is disorganized
exencephaly ( J:172044 )
• increasing incidence of exencephaly from E13.5 to E14.5
• exencephalic mass consists of greatly expanded neural progenitors
increased neuronal precursor cell number ( J:172044 )
• exencephalic mass consists of greatly expanded neural progenitors




Genotype
MGI:5004977
cn2
Allelic
Composition		 Rhoatm1Yuyo/Rhoatm1Yuyo
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Rhoatm1Yuyo mutation (0 available); any Rhoa mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron proliferation ( J:172044 )
• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain
abnormal midbrain development ( J:172044 )
• around E11.5 multiple nodules are detected protruding from the apical surface of the mesencephalon and this phenotype becomes more severe by E12.5
• the cellular organization in the ventricular zone of the mesencephalon becomes highly irregular by E12.5
• after E12.5 dysplasia is seen in all embryos and by E13.5 dysplasia expands throughout the mesencephalon
• expansion of neural progenitor cells in the developing mesencephalon
abnormal midbrain morphology ( J:172044 )
• protrusions consisting of neuronal mass originating from the midbrain are exposed dorsally and push into the forebrain ventrally
• expression analysis indicates disruption of adherens junctions at the ventricular surface at E12.5
increased midbrain size ( J:172044 )
• enlarged at E13.5
exencephaly ( J:172044 )
• display exencephaly-like protrusions at E15.5
increased neuronal precursor cell number ( J:172044 )
• expansion of neural progenitor cells in the developing mesencephalon

cellular
abnormal neuron proliferation ( J:172044 )
• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory