Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
Rhoatm1Yuyo mutation
(0 available);
any
Rhoa mutation
(70 available)
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nervous system
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• the apical/ventricular surface is disorganized
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• increasing incidence of exencephaly from E13.5 to E14.5
• exencephalic mass consists of greatly expanded neural progenitors
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• exencephalic mass consists of greatly expanded neural progenitors
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Rhoatm1Yuyo mutation
(0 available);
any
Rhoa mutation
(70 available)
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nervous system
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• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain
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• around E11.5 multiple nodules are detected protruding from the apical surface of the mesencephalon and this phenotype becomes more severe by E12.5
• the cellular organization in the ventricular zone of the mesencephalon becomes highly irregular by E12.5
• after E12.5 dysplasia is seen in all embryos and by E13.5 dysplasia expands throughout the mesencephalon
• expansion of neural progenitor cells in the developing mesencephalon
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• protrusions consisting of neuronal mass originating from the midbrain are exposed dorsally and push into the forebrain ventrally
• expression analysis indicates disruption of adherens junctions at the ventricular surface at E12.5
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• display exencephaly-like protrusions at E15.5
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• expansion of neural progenitor cells in the developing mesencephalon
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cellular
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• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain
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