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Targeted Allele Detail
Symbol: Tfap2btm1Rbu
Name: transcription factor AP-2 beta; targeted mutation 1, Reinhard Buettner
MGI ID: MGI:2180473
Synonyms: AP-2Beta-, Tcfap2btm1Rbu
Gene: Tfap2b  Location: Chr1:19279138-19308800 bp, + strand  Genetic Position: Chr1, 6.19 cM, cytoband A2-A4
Alliance: Tfap2btm1Rbu page
Postaxial accessory digits in Tfap2btm1Rbu/Tfap2btm1Rbu mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:42260
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe insertion of a PGK-neo cassette disrupted exon 4, which encodes an essential DNA binding domain. Northern blot and Western blot analyses showed an absence of transcript and protein, respectively, in midbrain lysates obtained from homozygous mutant mice. (J:42260)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfap2b Mutation:  17 strains or lines available
Original:  J:42260 Moser M, et al., Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory