Tgfbr2^tm1Karl
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1Karl
• Name: transforming growth factor, beta receptor II; targeted mutation 1, Stefan Karlsson
• MGI ID: MGI:2183502
• Synonyms: floxed-TbetaRII, T-Beta-RII flox, Tgfbr2fl, Tgfbr2^fl
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1Karl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77844
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was left flanked by single loxP sites in introns 3 and 5 after a floxed neo cassette was excised via cre-mediated recombination in ES cells. (J:77844)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr2^tm1Karl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 39 strains or lines available

References

• Original: J:77844 Leveen P, et al., Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002 Jul 15;100(2):560-8
• All: 124 reference(s)