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Tgfbr2tm1Karl
Targeted Allele Detail
Summary
Symbol: Tgfbr2tm1Karl
Name: transforming growth factor, beta receptor II; targeted mutation 1, Stefan Karlsson
MGI ID: MGI:2183502
Synonyms: floxed-TbetaRII, T-Beta-RII flox, Tgfbr2fl, Tgfbr2fl
Gene: Tgfbr2  Location: Chr9:115916763-116004431 bp, - strand  Genetic Position: Chr9, 68.39 cM
Alliance: Tgfbr2tm1Karl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77844
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 4 was left flanked by single loxP sites in introns 3 and 5 after a floxed neo cassette was excised via cre-mediated recombination in ES cells. (J:77844)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 22 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tgfbr2tm1Karl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:  39 strains or lines available
References
Original:  J:77844 Leveen P, et al., Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002 Jul 15;100(2):560-8
All:  123 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory