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Targeted Allele Detail
Symbol: Tbx1tm2.1Bem
Name: T-box 1; targeted mutation 2.1, Bernice E Morrow
MGI ID: MGI:3619149
Synonyms: Tbx1flox, Tbx1tm1.1Bem
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm2.1Bem page
Fourth pharyngeal arch artery aplasia in Tbx1tm2.1Bem/Tbx1+ Tfap2atm1(cre)Moon/Tfap2a+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:105980
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exons 2 and 3 were flanked with loxP sites. The ATG is in exon 2. (J:105980)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 59 assay results
7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 31 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  34 strains or lines available
Original:  J:105980 Arnold JS, et al., Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory