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Phenotype Image Detail
Image
Caption Conditional ablation of Tbx1 in pharyngeal ectoderm results in fourth pharyngeal arch artery (PAA) aplasia. (A) Typical fourth PAA morphology in a Tbx1tm2.1Bem/Tbx1tm2.1Bem (Tbx1fl/fl) control embryo at E10.5, revealed by intracardiac ink injection. (B) Hypoplasia of the fourth PAA (arrow) in a conditionally heterozygous Tbx1tm2.1Bem/Tbx1+ Tfap2atm1(cre)Moon/Tfap2a+ (AP2aIRESCre;Tbx1+/fl) embryo at E10.5. Scale bar: 100 um.
Copyright This image is from Randall V, J Clin Invest 2009 Nov;119(11):3301-10 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154590
Associated
Alleles
Symbol Name
Tbx1tm2.1Bem T-box 1; targeted mutation 2.1, Bernice E Morrow
Tfap2atm1(cre)Moon transcription factor AP-2, alpha; targeted mutation 1, Anne M Moon
Associated
Genotypes
Allelic Composition Genetic Background
Tbx1tm2.1Bem/Tbx1+
Tfap2atm1(cre)Moon/Tfap2a+
either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory