Sox4^tm1Vlf
Targeted Allele Detail

Summary

• Symbol: Sox4^tm1Vlf
• Name: SRY (sex determining region Y)-box 4; targeted mutation 1, Veronique Lefebvre
• MGI ID: MGI:3773012
• Synonyms: Sox4^fl, Sox4^loxP
• Gene: Sox4 Location: Chr13:29132902-29137682 bp, - strand Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
• Alliance: Sox4^tm1Vlf page

Decrease in retinal ganglion cells in single Sox11^tm1.1Gan and Sox4^tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 retinas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130461
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of the coding region and an additional loxP site was inserted upstream of the coding region. The neo cassette was removed by germ-line, flp-mediated recombination. (J:130461)

Expression

In Mice Carrying this Mutation:	26 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox4 Mutation: 20 strains or lines available

References

• Original: J:130461 Penzo-Mendez A, et al., Generation of mice harboring a Sox4 conditional null allele. Genesis. 2007 Dec;45(12):776-80
• All: 34 reference(s)