Phenotypes associated with this allele
Allelic
Composition |
Sox4tm1Vlf/Sox4tm1Vlf
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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normal phenotype
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• mice look and behave normally
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Sox11tm2.1Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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embryo
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• massive cell death in the branchial arches without a decrease in cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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mortality/aging
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• when treated with tamoxifen, mice die between E13.5 and E14.5 likely due to regurgitation of blood into the heart
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cardiovascular system
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• when treated with tamoxifen
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• endocardial cushions form at the level of the semilunar valve but functional flaps do not form when treated with tamoxifen
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• at E13.5, mice exhibit incomplete septation of the ventricles when treated with tamoxifen
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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embryo
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• increased cell death without a decrease in cell proliferation
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nervous system
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• increased cell death without a decrease in cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.1Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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limbs/digits/tail
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• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation
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embryo
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• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.1Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox12tm2.1Weg mutation
(0 available);
any
Sox12 mutation
(8 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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limbs/digits/tail
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• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation
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embryo
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• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Gan mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Six3-cre)69Frty mutation
(2 available)
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Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas
mortality/aging
vision/eye
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• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
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• only a few cells present at E12.5
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• impaired retinal ganglion cell development
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growth/size/body
cellular
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• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
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nervous system
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• only a few cells present at E12.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Six3-cre)69Frty mutation
(2 available)
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Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas
vision/eye
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N |
• mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells
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• 2-fold increase starting at E14.5
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• impaired retinal ganglion cell development
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• reduced number of axon bundles in the retina
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• in the inner nuclear layer and ganglion cell layer
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• beginning at E16.5
• moderate at P0 and in adult mice
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cellular
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• 2-fold increase starting at E14.5
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• reduced in retinal axon bundles
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nervous system
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• reduced in retinal axon bundles
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• in the inner nuclear layer and ganglion cell layer
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• beginning at E16.5
• moderate at P0 and in adult mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.1Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Dbh-icre)1Gsc mutation
(0 available)
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vision/eye
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• Meibomian glands lack sympathetic innervation
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• unable to fully open their eyes
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nervous system
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• have only a small rudiment of the stellate ganglion
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• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
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• musculus tarsalis of the eyelid lacks sympathetic innervation
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endocrine/exocrine glands
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• Meibomian glands lack sympathetic innervation
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integument
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• Meibomian glands lack sympathetic innervation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Dbh-icre)1Gsc mutation
(0 available)
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nervous system
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• sympathetic ganglia are significantly smaller and have fewer cells at E11.5, E14.5 and E18.5
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• expression analysis indicates a delay in noradrenergic differentiation in the sympathetic ganglia
• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type
when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5
• the number of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5r of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Dbh-icre)1Gsc mutation
(0 available)
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nervous system
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• show mild reductions in size and cell number at E14.5 and are about two thirds the size of wild-type and have reduced cell numbers at E18.5
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• expression analysis indicates a transient delay in noradrenergic differentiation in the sympathetic ganglia
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Analysis Tools