Sox11^tm1Weg
Targeted Allele Detail

Summary

• Symbol: Sox11^tm1Weg
• Name: SRY (sex determining region Y)-box 11; targeted mutation 1, Michael Wegner
• MGI ID: MGI:3052744
• Synonyms: Sox11^-, Sox11^lacZ
• Gene: Sox11 Location: Chr12:27384263-27392573 bp, - strand Genetic Position: Chr12, 9.95 cM, cytoband A3
• Alliance: Sox11^tm1Weg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92251
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ORF was replaced with a lacZ-neo cassette. Southern blot confirmed recombination in embryos. Lack of transcript in mutant embryos was demonstrated by RT-PCR. X-Gal staining revealed lacZ expression in mutant embryos. (J:92251)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox11 Mutation: 14 strains or lines available

References

• Original: J:92251 Sock E, et al., Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol. 2004 Aug;24(15):6635-44
• All: 12 reference(s)