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Targeted Allele Detail
Symbol: Tbx1tm1Dsr
Name: T-box 1; targeted mutation 1, Deepak Srivastava
MGI ID: MGI:3510038
Synonyms: Tbx1neo
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm1Dsr page
Germline Transmission:  Earliest citation of germline transmission: J:93588
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsThis is a hypomorphic allele created by the insertion of an FRT-flanked neomycin resistance gene into intron 3, and loxP sites flanking exons 4-8, which encode the T-box region. RT-PCR from mutant embryos revealed that transcript levels were only 25% of the levels of wild-type. (J:93588)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  34 strains or lines available
Original:  J:93588 Hu T, et al., Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory