Dvl3^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Dvl3^tm1Awb
• Name: dishevelled segment polarity protein 3; targeted mutation 1, Anthony Wynshaw-Boris
• MGI ID: MGI:3831892
• Gene: Dvl3 Location: Chr16:20335732-20352760 bp, + strand Genetic Position: Chr16, 12.46 cM
• Alliance: Dvl3^tm1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142392
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment spanning from part of exon 2 through exon 7 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on E13.5 whole embryo extracts. (J:142392)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dvl3 Mutation: 38 strains or lines available

References

• Original: J:142392 Etheridge SL, et al., Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 2008 Nov;4(11):e1000259
• All: 5 reference(s)