Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation
(1 available);
any
Dvl3 mutation
(38 available)
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mortality/aging
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• despite being present in Mendelian ratios at E18.5, no mice survive to weaning
• however, survival can be rescued by expression of a Dvl1, Dvl2, or Dvl3 transgene
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cardiovascular system
homeostasis/metabolism
hearing/vestibular/ear
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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skeleton
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• some mice exhibit xiphoid bifircation also observed in some wild-type mice
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respiratory system
nervous system
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation
(1 available);
any
Dvl3 mutation
(38 available)
|
|
|
mortality/aging
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|
• however, survival can be rescued by expression of a Dvl1, Dvl2, or Dvl3 transgene
• Background Sensitivity: despite being present in Mendelian ratios at E18.5, only 4 of the expected 30 mice survive to weaning compared to no mice surviving on a pure 129S6/SvEvTac background
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cardiovascular system
homeostasis/metabolism
hearing/vestibular/ear
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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skeleton
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• some mice exhibit xiphoid bifircation also observed in some wild-type mice
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respiratory system
nervous system
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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cardiovascular system
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N |
• at E10.5, E14.5 and E18.5, secondary heart field development is normal
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nervous system
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N |
• at E10.5, E14.5 and E18.5, cardiac neural crest cell development is normal
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cardiovascular system
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• 50% of embryos (n=14) display cardiac defects
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cardiovascular system
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• all (3 of 3) embryos display cardiac defects
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cardiovascular system
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• 83% of embryos (n=12) display cardiac defects
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Allelic
Composition |
Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+
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Genetic
Background |
involves: 129S6/SvEvTac * A * Black Swiss |
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nervous system
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• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
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• some mice develop defects in rostral neural tube closure
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• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
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• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
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• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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cardiovascular system
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N |
• hearts develop normally
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hearing/vestibular/ear
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• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
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• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
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• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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• in mice with neural tube defects
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embryo
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• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
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• some mice develop defects in rostral neural tube closure
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nervous system
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• some mice develop similar neural tube defects as in Dvl3tm1Awb Vangl2Lp double heterozygotes
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• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
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• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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cardiovascular system
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• mice exhibit conotruncal defects
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hearing/vestibular/ear
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• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
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• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
|
|
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• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts
• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
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• in mice with neural tube defects
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embryo
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• some mice develop similar neural tube defects as in Dvl3tm1Awb Vangl2Lp double heterozygotes
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Allelic
Composition |
Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
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Genetic
Background |
involves: 129S6/SvEvTac * Black Swiss |
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cardiovascular system
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• at E18.5, 11 of 28 mice exhibit conotruncal defects
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hearing/vestibular/ear
nervous system
mortality/aging
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• mice die between E13.5 and E15.5
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nervous system
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N |
• mice exhibit normal neural tube development
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mortality/aging
cardiovascular system
embryo
nervous system
homeostasis/metabolism
cardiovascular system
craniofacial
embryo
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• at E18.5, mice exhibit shortening along the anterior-posterior axis
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growth/size/body
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• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail
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hearing/vestibular/ear
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• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis
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limbs/digits/tail
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• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail
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nervous system
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• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis
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Analysis Tools