Kdm6atm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Kdm6atm1c(EUCOMM)Wtsi |
Name: |
lysine (K)-specific demethylase 6A; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5516010 |
Synonyms: |
Utxfl, XUtxGT2fl |
Gene: |
Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
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Alliance: |
Kdm6atm1c(EUCOMM)Wtsi page
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IMPC: |
Kdm6a gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:201868
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_gt0 cassette was inserted at position 18064967 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 18065789. The critical exon is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:201868)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:201868 Shpargel KB, et al., UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet. 2012 Sep;8(9):e1002964 |
All: |
14 reference(s) |
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