Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1c(EUCOMM)Wtsi mutation
(1 available);
any
Kdm6a mutation
(38 available)
|
|
|
mortality/aging
nervous system
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• in about half of embryos
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embryo
|
• in about half of embryos
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mortality/aging
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• no females recovered at E18.5
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mortality/aging
N |
• males recovered at expected frequencies at E18.5
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craniofacial
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• in some cases the palatine bone fails to fuse at the midline
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embryo
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• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation
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digestive/alimentary system
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• in some cases the palatine bone fails to fuse at the midline
|
nervous system
|
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation
|
growth/size/body
|
• in some cases the palatine bone fails to fuse at the midline
|
craniofacial
|
• in some cases the palatine bone fails to fuse at the midline
|
embryo
|
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation
|
digestive/alimentary system
|
• in some cases the palatine bone fails to fuse at the midline
|
nervous system
|
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation
|
growth/size/body
|
• in some cases the palatine bone fails to fuse at the midline
|
Allelic Composition |
Kdm6atm1c(EUCOMM)Wtsi/Y
|
|
Genetic Background |
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1c(EUCOMM)Wtsi mutation
(1 available);
any
Kdm6a mutation
(38 available)
|
|
|
mortality/aging
|
• hemizygous males are reduced 55% from expected numbers
• numbers at E18.5 were as expected
|