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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kdm6atm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5516010
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) MGI:5516065
cn2
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) MGI:5516066
cn3
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) MGI:5516067
cn4
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA MGI:7333177
cn5
Kdm6atm1c(EUCOMM)Wtsi/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA MGI:7333176
ot6
Kdm6atm1c(EUCOMM)Wtsi/Y either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) MGI:5516064


Genotype
MGI:5516065
hm1
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Genetic
Background
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• in about half of embryos

embryo
• in about half of embryos




Genotype
MGI:5516066
cn2
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5516067
cn3
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• males recovered at expected frequencies at E18.5




Genotype
MGI:7333177
cn4
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: C57BL/6J * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline

embryo
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

digestive/alimentary system
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline

nervous system
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

growth/size/body
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline




Genotype
MGI:7333176
cn5
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: C57BL/6J * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline

embryo
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

digestive/alimentary system
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline

nervous system
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

growth/size/body
• partially penetrant
• in some cases the palatine bone fails to fuse at the midline




Genotype
MGI:5516064
ot6
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Y
Genetic
Background
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• hemizygous males are reduced 55% from expected numbers
• numbers at E18.5 were as expected





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory